TAFA2
Chemokine-like protein TAFA-2
Also known as: FAM19A2, TAFA-2, TAFA2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N3H0
- Gene
- TAFA2
- Ensembl
- ENSG00000198673
- Chromosome
- 12
- Canonical length
- 131 aa
- Protein class
- Predicted intracellular proteins
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
131 residues, UniProt reviewed canonical sequence.
>Q8N3H0|TAFA2
1 MSKRYLQKAT KGKLLIIIFI VTLWGKVVSS ANHHKAHHVK TGTCEVVALH RCCNKNKIEE
61 RSQTVKCSCF PGQVAGTTRA APSCVDASIV EQKWWCHMQP CLEGEECKVL PDRKGWSCSS
121 GNKVKTTRVT HLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TAFA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 18 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 18 nTPM
- amygdala: 12 nTPM
- hippocampal formation: 9.4 nTPM
- seminal vesicle: 6.8 nTPM
- hypothalamus: 5.2 nTPM
- ovary: 4.8 nTPM
Single-cell type
- hematopoietic stem cells: 2,116 nCPM
- neutrophils: 755 nCPM
- neutrophil progenitors: 753 nCPM
- brain excitatory neurons: 696 nCPM
- oligodendrocyte progenitor cells: 692 nCPM
- megakaryocyte-erythroid progenitors: 651 nCPM
Immune cell
- basophil: 32 nTPM
- neutrophil: 12 nTPM
- eosinophil: 5.2 nTPM
- T-reg: 3.9 nTPM
- classical monocyte: 2.4 nTPM
- memory CD4 T-cell: 1 nTPM
Brain region
- cerebral cortex: 68 nTPM
- hippocampal formation: 46 nTPM
- basal ganglia: 38 nTPM
- pons: 33 nTPM
- amygdala: 31 nTPM
- white matter: 30 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.73
- gnomAD pLI
- 0.34
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TAFA2 as an antibody target. Whether an autoantibody or antibody against TAFA2 could matter depends on whether native TAFA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TAFA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TAFA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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