Peptidase S26

Definition

This entry represents a domain found in some members of the S26A family of serine endopeptidases. Peptidases S26A (signal peptidase I) removes the hydrophobic, N-terminal signal peptides as proteins are translocated across membranes. The type I signal peptidases are unique serine proteases that utilize a serine/lysine catalytic dyad mechanism in place of the classical serine/histidine/aspartic acid catalytic triad mechanism PMID:15546672. Peptidases S26B includes eukaryotic microsomal signal peptidases involved in the removal of signal peptides from secretory proteins as they pass into the endoplasmic reticulum lumen PMID:7845208. Peptidases 26C (TraF signal peptidase) are found in operons that encode elements of conjugative transfer systems.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• IMMP1L
• IMMP2L
• SEC11A
• SEC11B
• SEC11C