Seroatlas · Human Serome Atlas

IMMP2L

Mitochondrial inner membrane protease subunit 2

Also known as: IMMP2L-IT1, IMP2, IMP2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96T52
Gene
IMMP2L
Ensembl
ENSG00000184903
Chromosome
7
Canonical length
175 aa
Protein class
Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Mitochondria,Flagellar centriole,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>Q96T52|IMMP2L
     1  MAQSQGWVKR YIKAFCKGFF VAVPVAVTFL DRVACVARVE GASMQPSLNP GGSQSSDVVL
    61  LNHWKVRNFE VHRGDIVSLV SPKNPEQKII KRVIALEGDI VRTIGHKNRY VKVPRGHIWV
   121  EGDHHGHSFD SNSFGPVSLG LLHAHATHIL WPPERWQKLE SVLPPERLPV QREEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IMMP2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 32 nTPM
  • skeletal muscle: 26 nTPM
  • liver: 24 nTPM
  • tongue: 24 nTPM
  • thyroid gland: 22 nTPM
  • blood vessel: 21 nTPM

Single-cell type

  • retinal pigment epithelial cells: 2,213 nCPM
  • renal connecting tubule cells: 2,092 nCPM
  • pituicytes/fscs: 1,916 nCPM
  • renal collecting duct principal cells: 1,682 nCPM
  • loop of henle epithelial cells: 1,648 nCPM
  • choroid plexus epithelial cells: 1,586 nCPM

Immune cell

  • NK-cell: 47 nTPM
  • naive B-cell: 39 nTPM
  • memory B-cell: 29 nTPM
  • naive CD4 T-cell: 25 nTPM
  • plasmacytoid DC: 21 nTPM
  • MAIT T-cell: 20 nTPM

Brain region

  • choroid plexus: 27 nTPM
  • white matter: 23 nTPM
  • basal ganglia: 23 nTPM
  • hypothalamus: 23 nTPM
  • cerebral cortex: 21 nTPM
  • midbrain: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IMMP2L.

Disease | AllUniProt

Conditions IMMP2L is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0.01
gnomAD missense Z
0.17
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IMMP2L as an antibody target. Whether an autoantibody or antibody against IMMP2L could matter depends on whether native IMMP2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IMMP2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IMMP2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IMMP2L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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