Seroatlas · Human Serome Atlas

IMMP1L

Mitochondrial inner membrane protease subunit 1

Also known as: FLJ25059, IMMP1, IMP1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LU5
Gene: IMMP1L
Ensembl: ENSG00000148950
Chromosome: 11
Canonical length: 166 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM, Sep 2008]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>Q96LU5|IMMP1L
     1  MLRGVLGKTF RLVGYTIQYG CIAHCAFEYV GGVVMCSGPS MEPTIQNSDI VFAENLSRHF
    61  YGIQRGDIVI AKSPSDPKSN ICKRVIGLEG DKILTTSPSD FFKSHSYVPM GHVWLEGDNL
   121  QNSTDSRCYG PIPYGLIRGR IFFKIWPLSD FGFLRASPNG HRFSDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IMMP1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 47 nTPM
cerebellum: 46 nTPM
basal ganglia: 46 nTPM
amygdala: 41 nTPM
tongue: 40 nTPM
cerebral cortex: 36 nTPM

Single-cell type

parietal cells: 216 nCPM
myonuclei: 174 nCPM
corticotrophs: 156 nCPM
retinal horizontal cells: 122 nCPM
distal convoluted tubule cells: 121 nCPM
pancreatic islet cells: 119 nCPM

Immune cell

plasmacytoid DC: 40 nTPM
naive CD8 T-cell: 40 nTPM
NK-cell: 38 nTPM
T-reg: 36 nTPM
memory B-cell: 34 nTPM
eosinophil: 32 nTPM

Brain region

cerebellum: 15 nTPM
basal ganglia: 11 nTPM
white matter: 10 nTPM
cerebral cortex: 10 nTPM
thalamus: 9.4 nTPM
spinal cord: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

serine-type endopeptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptidase S26A, signal peptidase I
Peptidase S26
LexA/Signal peptidase-like superfamily
Signal peptidase, peptidase S26
Mitochondrial Inner Membrane Protease Subunit 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IMMP1L as an antibody target. Whether an autoantibody or antibody against IMMP1L could matter depends on whether native IMMP1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IMMP1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IMMP1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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