SEC11B
Putative signal peptidase complex catalytic subunit SEC11B
Also known as: SC11B_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for SEC11B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
166 residues, UniProt reviewed canonical sequence.
>P0C7V7|SEC11B
1 MNKWRLYYQV LNFGMIVSSA LMIWKGLMVI TGSESPIVLL SGSMEPAFHR GYLLFLTNRV
61 EDPIRVGEIA VLRIEGRKIP IVHRVLKIHE KQNGHIKFLT KGDNNAVDDR GLYKQDQHWL
121 EKKDVVGRAR GFVPYIGIGT SLMNDYPKHK YEVLFLLGLF VLVHRELocalizationUniProt · AlphaFold · HPA
Whether an antibody against SEC11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.37
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SEC11B as an antibody target. Whether an autoantibody or antibody against SEC11B could matter depends on whether native SEC11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SEC11B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SEC11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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