P-type trefoil, conserved site

Definition

A cysteine-rich domain of approximately forty five amino-acid residues has been found in some extracellular eukaryotic proteins [[cite:PMID:7820556], [cite:PMID:9187350], [cite:PMID:8518738], [cite:PMID:8267796]]. It is known as either the 'P', 'trefoil' or 'TFF' domain, and contains six cysteines linked by three disulphide bonds with connectivity 1-5, 2-4, 3-6. The domain has been found in a variety of extracellular eukaryotic proteins [[cite:PMID:7820556], [cite:PMID:8518738], [cite:PMID:8267796]], including protein pS2 (TFF1), a protein secreted by the stomach mucosa; spasmolytic polypeptide (SP) (TFF2), a protein of about 115 residues that inhibits gastrointestinal motility and gastric acid secretion; intestinal trefoil factor (ITF) (TFF3); Xenopus laevis stomach proteins xP1 and xP4; Xenopus integumentary mucins A.1 (FIM-A.1 or preprospasmolysin) and C.1 (FIM-C.1), proteins which may be involved in defence against microbial infections by protecting the epithelia from the external environment; Xenopus skin protein xp2 (or APEG); Zona pellucida sperm-binding protein B (ZP-B); intestinal sucrase-isomaltase ([ec:3.2.1.48] / [ec:3.2.1.10]), a vertebrate membrane bound, multifunctional enzyme complex which hydrolyses sucrose, maltose and isomaltose; and lysosomal alpha-glucosidase ([ec:3.2.1.20]).

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• GAA
• MGAM
• SI
• TFF1
• TFF2
• TFF3
• ZP1
• ZP4