Seroatlas · Human Serome Atlas

TFF2

Trefoil factor 2

Also known as: SML1, TFF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q03403
Gene: TFF2
Ensembl: ENSG00000160181
Chromosome: 21
Canonical length: 129 aa
Protein class: Cancer-related genes, Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

129 residues, UniProt reviewed canonical sequence.

>Q03403|TFF2
     1  MGRRDAQLLA ALLVLGLCAL AGSEKPSPCQ CSRLSPHNRT NCGFPGITSD QCFDNGCCFD
    61  SSVTGVPWCF HPLPKQESDQ CVMEVSDRRN CGYPGISPEE CASRKCCFSN FIFEVPWCFF
   121  PKSVEDCHY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TFF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 6,463 nTPM

Expression across tissuesHPA

Tissue

stomach: 6,463 nTPM
duodenum: 1,343 nTPM
gallbladder: 99 nTPM
pancreas: 20 nTPM
rectum: 3.9 nTPM
liver: 3.8 nTPM

Single-cell type

foveolar cells: 11,063 nCPM
cholangiocytes: 1,686 nCPM
mucous neck cells: 777 nCPM
gastric chief cells: 611 nCPM
gastric progenitor cells: 431 nCPM
pancreatic duct cells: 214 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: 0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

CXCR4 chemokine receptor binding

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TFF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GKN2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TFF2 as an antibody target. Whether an autoantibody or antibody against TFF2 could matter depends on whether native TFF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TFF2 is annotated as secreted, so native TFF2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TFF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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