Seroatlas · Human Serome Atlas

TFF1

Trefoil factor 1

Also known as: BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2, TFF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P04155
Gene: TFF1
Ensembl: ENSG00000160182
Chromosome: 21
Canonical length: 84 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

84 residues, UniProt reviewed canonical sequence.

>P04155|TFF1
     1  MATMENKVIC ALVLVSMLAL GTLAEAQTET CTVAPRERQN CGFPGVTPSQ CANKGCCFDD
    61  TVRGVPWCFY PNTIDVPPEE ECEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TFF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 7,509 nTPM

Expression across tissuesHPA

Tissue

stomach: 7,509 nTPM
gallbladder: 157 nTPM
colon: 107 nTPM
rectum: 101 nTPM
small intestine: 64 nTPM
salivary gland: 37 nTPM

Single-cell type

foveolar cells: 32,436 nCPM
goblet cells: 2,902 nCPM
gastric progenitor cells: 1,387 nCPM
breast hormone-responsive cells: 792 nCPM
prostatic club cells: 621 nCPM
neuroendocrine cells: 601 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

growth factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TFF1 as an antibody target. Whether an autoantibody or antibody against TFF1 could matter depends on whether native TFF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TFF1 is annotated as secreted, so native TFF1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TFF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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