Seroatlas · Human Serome Atlas

ZP1

Zona pellucida sperm-binding protein 1

Also known as: ZP1_HUMAN, ZPB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60852
Gene
ZP1
Ensembl
ENSG00000149506
Chromosome
11
Canonical length
638 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted in female reproductive system
Quaternary structure
Homodimer

OverviewNCBI Gene

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

638 residues, UniProt reviewed canonical sequence.

>P60852|ZP1
     1  MAGGSATTWG YPVALLLLVA TLGLGRWLQP DPGLPGLRHS YDCGIKGMQL LVFPRPGQTL
    61  RFKVVDEFGN RFDVNNCSIC YHWVTSRPQE PAVFSADYRG CHVLEKDGRF HLRVFMEAVL
   121  PNGRVDVAQD ATLICPKPDP SRTLDSQLAP PAMFSVSTPQ TLSFLPTSGH TSQGSGHAFP
   181  SPLDPGHSSV HPTPALPSPG PGPTLATLAQ PHWGTLEHWD VNKRDYIGTH LSQEQCQVAS
   241  GHLPCIVRRT SKEACQQAGC CYDNTREVPC YYGNTATVQC FRDGYFVLVV SQEMALTHRI
   301  TLANIHLAYA PTSCSPTQHT EAFVVFYFPL THCGTTMQVA GDQLIYENWL VSGIHIQKGP
   361  QGSITRDSTF QLHVRCVFNA SDFLPIQASI FPPPSPAPMT QPGPLRLELR IAKDETFSSY
   421  YGEDDYPIVR LLREPVHVEV RLLQRTDPNL VLLLHQCWGA PSANPFQQPQ WPILSDGCPF
   481  KGDSYRTQMV ALDGATPFQS HYQRFTVATF ALLDSGSQRA LRGLVYLFCS TSACHTSGLE
   541  TCSTACSTGT TRQRRSSGHR NDTARPQDIV SSPGPVGFED SYGQEPTLGP TDSNGNSSLR
   601  PLLWAVLLLP AVALVLGFGV FVGLSQTWAQ KLWESNRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 0.5 nTPM
  • thymus: 0.3 nTPM
  • epididymis: 0.2 nTPM
  • prostate: 0.2 nTPM
  • ovary: 0.1 nTPM
  • parathyroid gland: 0.1 nTPM

Single-cell type

  • late spermatids: 139 nCPM
  • early spermatids: 33 nCPM
  • late primary spermatocytes: 21 nCPM
  • oocytes: 9.2 nCPM
  • lactotrophs: 5.9 nCPM
  • somatotrophs: 5.6 nCPM

Immune cell

  • plasmacytoid DC: 3.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.8 nTPM
  • cerebellum: 0.6 nTPM
  • basal ganglia: 0.4 nTPM
  • amygdala: 0.3 nTPM
  • hippocampal formation: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZP1.

Disease | AllUniProt

Conditions ZP1 is implicated in, by any mechanism.

  • Oocyte/zygote/embryo maturation arrest 1 (OZEMA1) MIM:615774

Disease | GeneticClinVar

16 pathogenic / likely-pathogenic of 152 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.33
gnomAD pLI
0
gnomAD missense Z
0.18
DepMap mean gene effect
-0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZP1 as an antibody target. Whether an autoantibody or antibody against ZP1 could matter depends on whether native ZP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZP1 is annotated at the cell surface, where native ZP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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