Carbohydrate sulfotransferase
IPR016469
Definition
This entry represents carbohydrate sulphotransferase, which catalyses the transfer of a sulphate to position 6 of the galactose (Gal) residues in keratan. It may function in the sulphation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins and participate in the biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Carbohydrate sulphotransferase CHST1, CHST2, CHST3, and CHST4 are all involved in producing functional L-selectin ligands PMID:11310842. Deficiency of CHST3 (also known as chondroitin-6-sulphotransferase) has been associated with severe chondrodysplasia with progressive spinal involvement PMID:18513679. Macular corneal dystrophy (MCD) has also been shown to be caused by mutations in the carbohydrate sulphotransferase 6 gene (CHST6) PMID:11139648.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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