ATP-grasp fold, subdomain 1
IPR013815
Definition
This entry represents subdomain 1 found at the N-terminal end of the ATP-grasp domain. The ATP-grasp fold is one of several distinct ATP-binding folds, and is found in enzymes that catalyse the formation of amide bonds, catalysing the ATP-dependent ligation of a carboxylate-containing molecule to an amino or thiol group-containing molecule PMID:9416615. This fold is found in many different enzyme families, including various peptide synthetases, biotin carboxylase, synapsin, succinyl-CoA synthetase, pyruvate phosphate dikinase, and glutathione synthetase, amongst others PMID:12392708. These enzymes contribute predominantly to macromolecular synthesis, using ATP-hydrolysis to activate their substrates.
13 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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