Seroatlas · Human Serome Atlas

RIMKLB

Beta-citrylglutamate synthase B

Also known as: FAM80B, KIAA1238, NAAGS, NAAGS-I, RIMKB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULI2
Gene: RIMKLB
Ensembl: ENSG00000166532
Chromosome: 12
Canonical length: 386 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centriolar satellite

OverviewNCBI Gene

Predicted to enable N-acetyl-L-aspartate-L-glutamate ligase activity and citrate-L-glutamate ligase activity. Predicted to be involved in glutamine family amino acid metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>Q9ULI2|RIMKLB
     1  MCSSVAAKLW FLTDRRIRED YPQKEILRAL KAKCCEEELD FRAVVMDEVV LTIEQGNLGL
    61  RINGELITAY PQVVVVRVPT PWVQSDSDIT VLRHLEKMGC RLMNRPQAIL NCVNKFWTFQ
   121  ELAGHGVPLP DTFSYGGHEN FAKMIDEAEV LEFPMVVKNT RGHRGKAVFL ARDKHHLADL
   181  SHLIRHEAPY LFQKYVKESH GRDVRVIVVG GRVVGTMLRC STDGRMQSNC SLGGVGMMCS
   241  LSEQGKQLAI QVSNILGMDV CGIDLLMKDD GSFCVCEANA NVGFIAFDKA CNLDVAGIIA
   301  DYAASLLPSG RLTRRMSLLS VVSTASETSE PELGPPASTA VDNMSASSSS VDSDPESTER
   361  ELLTKLPGGL FNMNQLLANE IKLLVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIMKLB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 60 nTPM
endometrium: 38 nTPM
fallopian tube: 32 nTPM
testis: 30 nTPM
cerebellum: 29 nTPM
cervix: 29 nTPM

Single-cell type

endometrial glandular cells: 5,303 nCPM
endometrial luminal cells: 1,415 nCPM
late spermatids: 543 nCPM
syncytiotrophoblasts: 398 nCPM
alveolar cells type 2: 347 nCPM
early spermatids: 258 nCPM

Immune cell

basophil: 2.1 nTPM
naive CD4 T-cell: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM
naive B-cell: 1.3 nTPM
classical monocyte: 1.2 nTPM
NK-cell: 1.2 nTPM

Brain region

medulla oblongata: 54 nTPM
spinal cord: 51 nTPM
midbrain: 46 nTPM
hypothalamus: 46 nTPM
cerebellum: 43 nTPM
basal ganglia: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.59
gnomAD missense Z: 2.34
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding
metal ion binding
N-acetyl-L-aspartate-L-glutamate ligase activity
citrate-L-glutamate ligase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIMKLB as an antibody target. Whether an autoantibody or antibody against RIMKLB could matter depends on whether native RIMKLB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIMKLB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIMKLB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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