Seroatlas · Human Serome Atlas

RIMKLA

N-acetylaspartylglutamate synthase A

Also known as: FAM80A, MGC47816, NAAGS-II, RIMKA_HUMAN, RP11-157D18.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXN7
Gene: RIMKLA
Ensembl: ENSG00000177181
Chromosome: 1
Canonical length: 391 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to enable N-acetyl-L-aspartate-L-glutamate ligase activity. Predicted to be involved in glutamine family amino acid metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>Q8IXN7|RIMKLA
     1  MCSQLWFLTD RRIREDYPQV QILRALRQRC SEQDVRFRAV LMDQIAVTIV GGHLGLQLNQ
    61  KALTTFPDVV LVRVPTPSVQ SDSDITVLRH LEKLGCRLVN RPQSILNCIN KFWTFQELAG
   121  HGVPMPDTFS YGGHEDFSKM IDEAEPLGYP VVVKSTRGHR GKAVFLARDK HHLSDICHLI
   181  RHDVPYLFQK YVKESHGKDI RVVVVGGQVI GSMLRCSTDG RMQSNCSLGG VGVKCPLTEQ
   241  GKQLAIQVSN ILGMDFCGID LLIMDDGSFV VCEANANVGF LAFDQACNLD VGGIIADYTM
   301  SLLPNRQTGK MAVLPGLSSP REKNEPDGCA SAQGVAESVY TINSGSTSSE SEPELGEIRD
   361  SSASTMGAPP SMLPEPGYNI NNRIASELKL K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIMKLA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

retina: 10 nTPM
cerebral cortex: 7.9 nTPM
cerebellum: 4.2 nTPM
basal ganglia: 4 nTPM
hippocampal formation: 3.9 nTPM
midbrain: 3.7 nTPM

Single-cell type

oocytes: 180 nCPM
alveolar cells type 1: 80 nCPM
cone photoreceptor cells: 64 nCPM
retinal horizontal cells: 62 nCPM
rod photoreceptor cells: 56 nCPM
other brain neurons: 46 nCPM

Immune cell

MAIT T-cell: 0.3 nTPM
basophil: 0.2 nTPM
eosinophil: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM

Brain region

cerebral cortex: 44 nTPM
white matter: 25 nTPM
pons: 25 nTPM
thalamus: 25 nTPM
medulla oblongata: 24 nTPM
hippocampal formation: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 1.22
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIMKLA as an antibody target. Whether an autoantibody or antibody against RIMKLA could matter depends on whether native RIMKLA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIMKLA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIMKLA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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