Seroatlas · Human Serome Atlas

SYN3

Synapsin-3

Also known as: SYN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14994
Gene
SYN3
Ensembl
ENSG00000185666
Chromosome
22
Canonical length
580 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

580 residues, UniProt reviewed canonical sequence.

>O14994|SYN3
     1  MNFLRRRLSD SSFMANLPNG YMTDLQRPDS STSSPASPAM ERRHPQPLAA SFSSPGSSLF
    61  SSLSSAMKQA PQATSGLMEP PGPSTPIVQR PRILLVIDDA HTDWSKYFHG KKVNGEIEIR
   121  VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KVVSRSFKPD FILVRQHAYS MALGEDYRSL
   181  VIGLQYGGLP AVNSLYSVYN FCSKPWVFSQ LIKIFHSLGP EKFPLVEQTF FPNHKPMVTA
   241  PHFPVVVKLG HAHAGMGKIK VENQLDFQDI TSVVAMAKTY ATTEAFIDSK YDIRIQKIGS
   301  NYKAYMRTSI SGNWKANTGS AMLEQVAMTE RYRLWVDSCS EMFGGLDICA VKAVHSKDGR
   361  DYIIEVMDSS MPLIGEHVEE DRQLMADLVV SKMSQLPMPG GTAPSPLRPW APQIKSAKSP
   421  GQAQLGPQLG QPQPRPPPQG GPRQAQSPQP QRSGSPSQQR LSPQGQQPLS PQSGSPQQQR
   481  SPGSPQLSRA SSGSSPNQAS KPGATLASQP RPPVQGRSTS QQGEESKKPA PPHPHLNKSQ
   541  SLTNSLSTSD TSQRGTPSED EAKAETIRNL RKSFASLFSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
5 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 5 nTPM
  • testis: 3.5 nTPM
  • retina: 3.3 nTPM
  • amygdala: 2.8 nTPM
  • basal ganglia: 2.8 nTPM
  • hippocampal formation: 2.4 nTPM

Single-cell type

  • retinal ganglion cells: 1,286 nCPM
  • cardiomyocytes: 977 nCPM
  • thyrotrophs: 769 nCPM
  • epicardial cells: 657 nCPM
  • brain inhibitory neurons: 558 nCPM
  • pericytes: 523 nCPM

Immune cell

  • naive B-cell: 3.2 nTPM
  • neutrophil: 1.6 nTPM
  • basophil: 0.9 nTPM
  • classical monocyte: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM

Brain region

  • cerebral cortex: 173 nTPM
  • amygdala: 132 nTPM
  • pons: 122 nTPM
  • hippocampal formation: 109 nTPM
  • white matter: 99 nTPM
  • medulla oblongata: 89 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SYN3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 102 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0
gnomAD missense Z
1.04
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYN3 as an antibody target. Whether an autoantibody or antibody against SYN3 could matter depends on whether native SYN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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