SUCLG2

Protein identityUniProt · HPA

UniProt accession

Q96I99

Gene

SUCLG2

Ensembl

ENSG00000172340

Chromosome

3

Canonical length

432 aa

Protein class

Citric acid cycle related proteins, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Mitochondria

OverviewNCBI Gene

This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q96I99|SUCLG2
     1  MASPVAAQAG KLLRALALRP RFLAAGSQAV QLTSRRWLNL QEYQSKKLMS DNGVRVQRFF
    61  VADTANEALE AAKRLNAKEI VLKAQILAGG RGKGVFNSGL KGGVHLTKDP NVVGQLAKQM
   121  IGYNLATKQT PKEGVKVNKV MVAEALDISR ETYLAILMDR SCNGPVLVGS PQGGVDIEEV
   181  AASNPELIFK EQIDIFEGIK DSQAQRMAEN LGFVGPLKSQ AADQITKLYN LFLKIDATQV
   241  EVNPFGETPE GQVVCFDAKI NFDDNAEFRQ KDIFAMDDKS ENEPIENEAA KYDLKYIGLD
   301  GNIACFVNGA GLAMATCDII FLNGGKPANF LDLGGGVKEA QVYQAFKLLT ADPKVEAILV
   361  NIFGGIVNCA IIANGITKAC RELELKVPLV VRLEGTNVQE AQKILNNSGL PITSAIDLED
   421  AAKKAVASVA KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUCLG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

260 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.5

gnomAD pLI

0

gnomAD missense Z

-0.49

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• succinate metabolic process
• succinyl-CoA catabolic process
• succinyl-CoA metabolic process
• tricarboxylic acid cycle

Molecular functions

• ATP binding
• GDP binding
• GTP binding
• magnesium ion binding
• protein-containing complex binding
• succinate-CoA ligase (GDP-forming) activity

Cellular components

• mitochondrial matrix
• mitochondrion
• plasma membrane
• succinate-CoA ligase complex
• succinate-CoA ligase complex (GDP-forming)

Protein domainsUniProt · Pfam · InterPro

• Succinate--CoA ligase-like, beta subunit
• ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain
• ATP-grasp fold, succinyl-CoA synthetase-type
• ATP-grasp fold, subdomain 1
• Succinyl-CoA synthetase-like
• Succinyl-CoA synthetase, beta subunit, conserved site
• CoA-ligase
• ATP-grasp domain
• Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

KeywordsUniProt

• Acetylation
• GTP-binding
• Ligase
• Magnesium
• Metal-binding
• Mitochondrion
• Nucleotide-binding
• Phosphoprotein
• Transit peptide
• Tricarboxylic acid cycle

InteractionsUniProt · HPA

Protein binding partners of SUCLG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SUCLG1