Seroatlas · Human Serome Atlas

NPAS1

Neuronal PAS domain-containing protein 1

Also known as: bHLHe11, MOP5, NPAS1_HUMAN, PASD5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99742
Gene: NPAS1
Ensembl: ENSG00000130751
Chromosome: 19
Canonical length: 590 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

590 residues, UniProt reviewed canonical sequence.

>Q99742|NPAS1
     1  MAAPYPGSGG GSEVKCVGGR GASVPWDFLP GLMVKAPSGP CLQAQRKEKS RNAARSRRGK
    61  ENLEFFELAK LLPLPGAISS QLDKASIVRL SVTYLRLRRF AALGAPPWGL RAAGPPAGLA
   121  PGRRGPAALV SEVFEQHLGG HILQSLDGFV FALNQEGKFL YISETVSIYL GLSQVEMTGS
   181  SVFDYIHPGD HSEVLEQLGL RTPTPGPPTP PSVSSSSSSS SSLADTPEIE ASLTKVPPSS
   241  LVQERSFFVR MKSTLTKRGL HVKASGYKVI HVTGRLRAHA LGLVALGHTL PPAPLAELPL
   301  HGHMIVFRLS LGLTILACES RVSDHMDLGP SELVGRSCYQ FVHGQDATRI RQSHVDLLDK
   361  GQVMTGYYRW LQRAGGFVWL QSVATVAGSG KSPGEHHVLW VSHVLSQAEG GQTPLDAFQL
   421  PASVACEEAS SPGPEPTEPE PPTEGKQAAP AENEAPQTQG KRIKVEPGPR ETKGSEDSGD
   481  EDPSSHPATP RPEFTSVIRA GVLKQDPVRP WGLAPPGDPP PTLLHAGFLP PVVRGLCTPG
   541  TIRYGPAELG LVYPHLQRLG PGPALPEAFY PPLGLPYPGP AGTRLPRKGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPAS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 10 nTPM
amygdala: 9.6 nTPM
hippocampal formation: 9.6 nTPM
skin: 7.6 nTPM
hypothalamus: 5.3 nTPM
choroid plexus: 3.5 nTPM

Single-cell type

oocytes: 152 nCPM
foveolar cells: 45 nCPM
cone photoreceptor cells: 29 nCPM
brain inhibitory neurons: 19 nCPM
müller glia: 13 nCPM
choroid plexus epithelial cells: 13 nCPM

Immune cell

memory B-cell: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 17 nTPM
hippocampal formation: 15 nTPM
pons: 12 nTPM
amygdala: 10 nTPM
medulla oblongata: 9.5 nTPM
hypothalamus: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 1.8
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NPAS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ARNT

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPAS1 as an antibody target. Whether an autoantibody or antibody against NPAS1 could matter depends on whether native NPAS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPAS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPAS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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