Galactose mutarotase-like domain superfamily
IPR011013
Definition
Proteins with this domain belong to the galactose mutarotase-like structural superfamily. The domain has a distorted supersandwich structure consisting of 18 strands in two sheets, and probably functions to bind carbohydrates in enzymes that act on sugars. Domains with this structure occur in several protein families, including galactose mutarotase ([ec:5.1.3.3]) PMID:11907040; domain 5 of beta-galactosidase ([ec:3.2.1.23]); domain 2 of Isomaltosyltransferase ([ec:2.4.1.387]); the central domain of hyaluronate lyase-like enzymes, such as chondroitinase AC ([ec:4.2.2.5]), xanthan lyase ([ec:4.2.2.12]), chrondroitin ABC lyase I, and hyaluronate lyase ([ec:4.2.2.1]) itself PMID:12829379; the N-terminal domain of lactobacillus maltose phosphorylase ([ec:2.4.1.8]), 6-glucosyltransferase ([ec:2.4.1.24]) and bacterial glucoamylase ([ec:3.2.1.3]) [[cite:PMID:11587643], [cite:PMID:12501412]]; the C-terminal domain of eukaryotic alpha-mannosidase ([ec:3.2.1.24]) and archaeon 4-alpha-glucanotransferase ([ec:2.4.1.25]) PMID:12618437.
12 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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