Seroatlas · Human Serome Atlas

MAN2A1

Alpha-mannosidase 2

Also known as: GOLIM7, MA2A1_HUMAN, MANA2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16706
Gene
MAN2A1
Ensembl
ENSG00000112893
Chromosome
5
Canonical length
1144 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

1144 residues, UniProt reviewed canonical sequence.

>Q16706|MAN2A1
     1  MKLSRQFTVF GSAIFCVVIF SLYLMLDRGH LDYPRNPRRE GSFPQGQLSM LQEKIDHLER
    61  LLAENNEIIS NIRDSVINLS ESVEDGPKSS QSNFSQGAGS HLLPSQLSLS VDTADCLFAS
   121  QSGSHNSDVQ MLDVYSLISF DNPDGGVWKQ GFDITYESNE WDTEPLQVFV VPHSHNDPGW
   181  LKTFNDYFRD KTQYIFNNMV LKLKEDSRRK FIWSEISYLS KWWDIIDIQK KDAVKSLIEN
   241  GQLEIVTGGW VMPDEATPHY FALIDQLIEG HQWLENNIGV KPRSGWAIDP FGHSPTMAYL
   301  LNRAGLSHML IQRVHYAVKK HFALHKTLEF FWRQNWDLGS VTDILCHMMP FYSYDIPHTC
   361  GPDPKICCQF DFKRLPGGRF GCPWGVPPET IHPGNVQSRA RMLLDQYRKK SKLFRTKVLL
   421  APLGDDFRYC EYTEWDLQFK NYQQLFDYMN SQSKFKVKIQ FGTLSDFFDA LDKADETQRD
   481  KGQSMFPVLS GDFFTYADRD DHYWSGYFTS RPFYKRMDRI MESHLRAAEI LYYFALRQAH
   541  KYKINKFLSS SLYTALTEAR RNLGLFQHHD AITGTAKDWV VVDYGTRLFH SLMVLEKIIG
   601  NSAFLLILKD KLTYDSYSPD TFLEMDLKQK SQDSLPQKNI IRLSAEPRYL VVYNPLEQDR
   661  ISLVSVYVSS PTVQVFSASG KPVEVQVSAV WDTANTISET AYEISFRAHI PPLGLKVYKI
   721  LESASSNSHL ADYVLYKNKV EDSGIFTIKN MINTEEGITL ENSFVLLRFD QTGLMKQMMT
   781  KEDGKHHEVN VQFSWYGTTI KRDKSGAYLF LPDGNAKPYV YTTPPFVRVT HGRIYSEVTC
   841  FFDHVTHRVR LYHIQGIEGQ SVEVSNIVDI RKVYNREIAM KISSDIKSQN RFYTDLNGYQ
   901  IQPRMTLSKL PLQANVYPMT TMAYIQDAKH RLTLLSAQSL GVSSLNSGQI EVIMDRRLMQ
   961  DDNRGLEQGI QDNKITANLF RILLEKRSAV NTEEEKKSVS YPSLLSHITS SLMNHPVIPM
  1021  ANKFSSPTLE LQGEFSPLQS SLPCDIHLVN LRTIQSKVGN GHSNEAALIL HRKGFDCRFS
  1081  SKGTGLFCST TQGKILVQKL LNKFIVESLT PSSLSLMHSP PGTQNISEIN LSPMEISTFR
  1141  IQLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAN2A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.21
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • liver: 40 nTPM
  • duodenum: 28 nTPM
  • small intestine: 24 nTPM
  • thymus: 21 nTPM
  • pancreas: 21 nTPM
  • parathyroid gland: 20 nTPM

Single-cell type

  • oligodendrocytes: 2,075 nCPM
  • megakaryocyte progenitors: 450 nCPM
  • mast cells: 429 nCPM
  • megakaryocyte-erythroid progenitors: 419 nCPM
  • sertoli cells: 410 nCPM
  • gonadotrophs: 379 nCPM

Immune cell

  • non-classical monocyte: 4.5 nTPM
  • basophil: 4.2 nTPM
  • naive CD4 T-cell: 3.3 nTPM
  • intermediate monocyte: 2.8 nTPM
  • memory CD4 T-cell: 2.8 nTPM
  • memory CD8 T-cell: 2.8 nTPM

Brain region

  • white matter: 238 nTPM
  • medulla oblongata: 159 nTPM
  • basal ganglia: 158 nTPM
  • pons: 132 nTPM
  • midbrain: 127 nTPM
  • thalamus: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAN2A1 as an antibody target. Whether an autoantibody or antibody against MAN2A1 could matter depends on whether native MAN2A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAN2A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.

Canonical record: https://seroatlas.com/gene/MAN2A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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