Seroatlas · Human Serome Atlas

MAN2A2

Alpha-mannosidase 2x

Also known as: HsT19662, MA2A2_HUMAN, MANA2X

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49641
Gene: MAN2A2
Ensembl: ENSG00000196547
Chromosome: 15
Canonical length: 1150 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytoplasmic bodies
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1150 residues, UniProt reviewed canonical sequence.

>P49641|MAN2A2
     1  MKLKKQVTVC GAAIFCVAVF SLYLMLDRVQ HDPTRHQNGG NFPRSQISVL QNRIEQLEQL
    61  LEENHEIISH IKDSVLELTA NAEGPPAMLP YYTVNGSWVV PPEPRPSFFS ISPQDCQFAL
   121  GGRGQKPELQ MLTVSEELPF DNVDGGVWRQ GFDISYDPHD WDAEDLQVFV VPHSHNDPGW
   181  IKTFDKYYTE QTQHILNSMV SKLQEDPRRR FLWAEVSFFA KWWDNINVQK RAAVRRLVGN
   241  GQLEIATGGW VMPDEANSHY FALIDQLIEG HQWLERNLGA TPRSGWAVDP FGYSSTMPYL
   301  LRRANLTSML IQRVHYAIKK HFAATHSLEF MWRQTWDSDS STDIFCHMMP FYSYDVPHTC
   361  GPDPKICCQF DFKRLPGGRI NCPWKVPPRA ITEANVAERA ALLLDQYRKK SQLFRSNVLL
   421  VPLGDDFRYD KPQEWDAQFF NYQRLFDFFN SRPNLHVQAQ FGTLSDYFDA LYKRTGVEPG
   481  ARPPGFPVLS GDFFSYADRE DHYWTGYYTS RPFYKSLDRV LEAHLRGAEV LYSLAAAHAR
   541  RSGLAGRYPL SDFTLLTEAR RTLGLFQHHD AITGTAKEAV VVDYGVRLLR SLVNLKQVII
   601  HAAHYLVLGD KETYHFDPEA PFLQVDDTRL SHDALPERTV IQLDSSPRFV VLFNPLEQER
   661  FSMVSLLVNS PRVRVLSEEG QPLAVQISAH WSSATEAVPD VYQVSVPVRL PALGLGVLQL
   721  QLGLDGHRTL PSSVRIYLHG RQLSVSRHEA FPLRVIDSGT SDFALSNRYM QVWFSGLTGL
   781  LKSIRRVDEE HEQQVDMQVL VYGTRTSKDK SGAYLFLPDG EAKPYVPKEP PVLRVTEGPF
   841  FSEVVAYYEH IHQAVRLYNL PGVEGLSLDI SSLVDIRDYV NKELALHIHT DIDSQGIFFT
   901  DLNGFQVQPR RYLKKLPLQA NFYPMPVMAY IQDAQKRLTL HTAQALGVSS LKDGQLEVIL
   961  DRRLMQDDNR GLGQGLKDNK RTCNRFRLLL ERRTVGSEVQ DSHSTSYPSL LSHLTSMYLN
  1021  APALALPVAR MQLPGPGLRS FHPLASSLPC DFHLLNLRTL QAEEDTLPSA ETALILHRKG
  1081  FDCGLEAKNL GFNCTTSQGK VALGSLFHGL DVVFLQPTSL TLLYPLASPS NSTDVYLEPM
  1141  EIATFRLRLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAN2A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 74 nTPM
retina: 70 nTPM
skeletal muscle: 65 nTPM
cerebellum: 54 nTPM
spinal cord: 53 nTPM
pancreas: 46 nTPM

Single-cell type

neutrophils: 213 nCPM
platelets: 128 nCPM
oligodendrocytes: 107 nCPM
erythrocyte progenitors: 83 nCPM
megakaryocyte-erythroid progenitors: 74 nCPM
myonuclei: 65 nCPM

Immune cell

basophil: 8.8 nTPM
neutrophil: 8 nTPM
non-classical monocyte: 3 nTPM
plasmacytoid DC: 1.6 nTPM
total PBMC: 1.4 nTPM
classical monocyte: 1.2 nTPM

Brain region

white matter: 189 nTPM
pons: 129 nTPM
medulla oblongata: 128 nTPM
basal ganglia: 128 nTPM
thalamus: 120 nTPM
midbrain: 118 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAN2A2.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 221 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental delay

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAN2A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MGAT4D

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAN2A2 as an antibody target. Whether an autoantibody or antibody against MAN2A2 could matter depends on whether native MAN2A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAN2A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAN2A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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