MAN2B2

Protein identityUniProt · HPA

UniProt accession

Q9Y2E5

Gene

MAN2B2

Ensembl

ENSG00000013288

Chromosome

4

Canonical length

1009 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process and oligosaccharide catabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1009 residues, UniProt reviewed canonical sequence.

>Q9Y2E5|MAN2B2
     1  MGQLCWLPLL APLLLLRPPG VQSAGPIRAF VVPHSHMDVG WVYTVQESMR AYAANVYTSV
    61  VEELARGQQR RFIAVEQEFF RLWWDGVASD QQKYQVRQLL EEGRLEFVIG GQVMHDEAVT
   121  HLDDQILQLT EGHGFLYETF GIRPQFSWHV DPFGASATTP TLFALAGFNA HLGSRIDYDL
   181  KAAMQEARGL QFVWRGSPSL SERQEIFTHI MDQYSYCTPS HIPFSNRSGF YWNGVAVFPK
   241  PPQDGVYPNM SEPVTPANIN LYAEALVANV KQRAAWFRTP HVLWPWGCDK QFFNASVQFA
   301  NMDPLLDHIN SHAAELGVSV QYATLGDYFR ALHALNVTWR VRDHHDFLPY STEPFQAWTG
   361  FYTSRSSLKG LARRASALLY AGESMFTRYL WPAPRGHLDP TWALQQLQQL RWAVSEVQHH
   421  DAITGTESPK VRDMYATHLA SGMLGMRKLM ASIVLDELQP QAPMAASSDA GPAGHFASVY
   481  NPLAWTVTTI VTLTVGFPGV RVTDEAGHPV PSQIQNSTET PSAYDLLILT TIPGLSYRHY
   541  NIRPTAGAQE GTQEPAATVA STLQFGRRLR RRTSHAGRYL VPVANDCYIV LLDQDTNLMH
   601  SIWERQSNRT VRVTQEFLEY HVNGDVKQGP ISDNYLFTPG KAAVPAWEAV EMEIVAGQLV
   661  TEIRQYFYRN MTAQNYTYAI RSRLTHVPQG HDGELLCHRI EQEYQAGPLE LNREAVLRTS
   721  TNLNSQQVIY SDNNGYQMQR RPYVSYVNNS IARNYYPMVQ SAFMEDGKSR LVLLSERAHG
   781  ISSQGNGQVE VMLHRRLWNN FDWDLGYNLT LNDTSVVHPV LWLLLGSWSL TTALRQRSAL
   841  ALQHRPVVLF GDLAGTAPKL PGPQQQEAVT LPPNLHLQIL SIPGWRYSSN HTEHSQNLRK
   901  GHRGEAQADL RRVLLRLYHL YEVGEDPVLS QPVTVNLEAV LQALGSVVAV EERSLTGTWD
   961  LSMLHRWSWR TGPGRHRGDT TSPSRPPGGP IITVHPKEIR TFFIHFQQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAN2B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.21

Highest tissue expression

49 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAN2B2.

Disease | AllUniProt

Conditions MAN2B2 is implicated in, by any mechanism.

• Congenital disorder of glycosylation 1EE with or without immunodeficiency (CDG1EE) MIM:621140

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 358 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital disorder of glycosylation type 1EE with or without immunodeficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.01

gnomAD pLI

0

gnomAD missense Z

-0.26

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• glycoprotein catabolic process
• mannose metabolic process
• oligosaccharide catabolic process

Molecular functions

• alpha-mannosidase activity
• carbohydrate binding
• metal ion binding
• mannan endo-1,6-alpha-mannosidase activity
• mannosyl-oligosaccharide 1,6-alpha-mannosidase activity

Cellular components

• extracellular exosome
• lysosomal lumen
• lysosome

Protein domainsUniProt · Pfam · InterPro

• Glycoside hydrolase family 38, N-terminal domain
• Galactose mutarotase-like domain superfamily
• Glycoside hydrolase/deacetylase, beta/alpha-barrel
• Glycosyl hydrolase family 38, C-terminal
• Glycosyl hydrolase, all-beta
• Glycoside hydrolase family 38, central domain
• Glycoside hydrolase 38, N-terminal domain superfamily
• Glycoside hydrolase families 57/38, central domain superfamily
• Glycoside hydrolase family 38, central domain superfamily
• Glycosyl Hydrolase Family 38
• Glycosyl hydrolases family 38 N-terminal domain
• Glycosyl hydrolases family 38 C-terminal domain
• Alpha mannosidase middle domain

KeywordsUniProt

• Congenital disorder of glycosylation
• Glycoprotein
• Glycosidase
• Hydrolase
• Metal-binding
• Secreted
• Signal
• Zinc