Seroatlas · Human Serome Atlas

GHITM

Growth hormone-inducible transmembrane protein

Also known as: DERP2, GHITM_HUMAN, HSPC282, My021, PTD010, TMBIM5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H3K2
Gene
GHITM
Ensembl
ENSG00000165678
Chromosome
10
Canonical length
345 aa
Protein class
Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables calcium:proton antiporter activity. Involved in calcium export from the mitochondrion; inner mitochondrial membrane organization; and negative regulation of release of cytochrome c from mitochondria. Located in endoplasmic reticulum membrane and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q9H3K2|GHITM
     1  MLAARLVCLR TLPSRVFHPA FTKASPVVKN SITKNQWLLT PSREYATKTR IGIRRGRTGQ
    61  ELKEAALEPS MEKIFKIDQM GRWFVAGGAA VGLGALCYYG LGLSNEIGAI EKAVIWPQYV
   121  KDRIHSTYMY LAGSIGLTAL SAIAISRTPV LMNFMMRGSW VTIGVTFAAM VGAGMLVRSI
   181  PYDQSPGPKH LAWLLHSGVM GAVVAPLTIL GGPLLIRAAW YTAGIVGGLS TVAMCAPSEK
   241  FLNMGAPLGV GLGLVFVSSL GSMFLPPTTV AGATLYSVAM YGGLVLFSMF LLYDTQKVIK
   301  RAEVSPMYGV QKYDPINSML SIYMDTLNIF MRVATMLATG GNRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GHITM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
425 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 425 nTPM
  • skeletal muscle: 343 nTPM
  • heart muscle: 340 nTPM
  • kidney: 279 nTPM
  • liver: 250 nTPM
  • cerebral cortex: 188 nTPM

Single-cell type

  • late spermatids: 3,987 nCPM
  • early spermatids: 1,201 nCPM
  • parietal cells: 1,086 nCPM
  • late primary spermatocytes: 599 nCPM
  • esophageal apical cells: 587 nCPM
  • esophageal suprabasal cells: 517 nCPM

Immune cell

  • total PBMC: 570 nTPM
  • intermediate monocyte: 301 nTPM
  • basophil: 290 nTPM
  • classical monocyte: 282 nTPM
  • non-classical monocyte: 278 nTPM
  • myeloid DC: 278 nTPM

Brain region

  • choroid plexus: 155 nTPM
  • cerebral cortex: 148 nTPM
  • hypothalamus: 147 nTPM
  • cerebellum: 130 nTPM
  • pons: 129 nTPM
  • thalamus: 128 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0.01
gnomAD missense Z
0.05
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GHITM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GHITM as an antibody target. Whether an autoantibody or antibody against GHITM could matter depends on whether native GHITM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GHITM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GHITM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GHITM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...