Seroatlas · Human Serome Atlas

GRINA

Protein lifeguard 1

Also known as: HNRGW, LFG1, LFG1_HUMAN, NMDARA1, TMBIM3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z429
Gene: GRINA
Ensembl: ENSG00000178719
Chromosome: 8
Canonical length: 371 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Predicted to enable calcium channel activity. Predicted to be involved in apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of neuron apoptotic process. Predicted to act upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>Q7Z429|GRINA
     1  MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS PYGQPGYPHG
    61  PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPQVF
   121  PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV
   181  SVFTFVAEVK GFVRENVWTY YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY
   241  MVGMIASFYN TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC
   301  IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN LYTDIINIFL
   361  YILTIIGRAK E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRINA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 427 nTPM

Expression across tissuesHPA

Tissue

liver: 427 nTPM
cerebellum: 311 nTPM
spleen: 298 nTPM
cerebral cortex: 290 nTPM
adipose tissue: 260 nTPM
testis: 258 nTPM

Single-cell type

late spermatids: 756 nCPM
neutrophils: 397 nCPM
syncytiotrophoblasts: 294 nCPM
kupffer cells: 286 nCPM
early spermatids: 283 nCPM
hepatocytes: 228 nCPM

Immune cell

intermediate monocyte: 36 nTPM
non-classical monocyte: 36 nTPM
classical monocyte: 32 nTPM
plasmacytoid DC: 23 nTPM
neutrophil: 19 nTPM
total PBMC: 16 nTPM

Brain region

thalamus: 263 nTPM
pons: 258 nTPM
hippocampal formation: 249 nTPM
midbrain: 248 nTPM
amygdala: 241 nTPM
medulla oblongata: 239 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.44
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRINA as an antibody target. Whether an autoantibody or antibody against GRINA could matter depends on whether native GRINA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRINA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRINA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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