Seroatlas · Human Serome Atlas

TMBIM4

Protein lifeguard 4

Also known as: CGI-119, GAAP, LFG4, LFG4_HUMAN, S1R, ZPRO

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HC24
Gene: TMBIM4
Ensembl: ENSG00000155957
Chromosome: 12
Canonical length: 238 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable calcium channel activity. Involved in negative regulation of apoptotic process and regulation of calcium-mediated signaling. Located in Golgi stack and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q9HC24|TMBIM4
     1  MADPDPRYPR SSIEDDFNYG SSVASATVHI RMAFLRKVYS ILSLQVLLTT VTSTVFLYFE
    61  SVRTFVHESP ALILLFALGS LGLIFALILN RHKYPLNLYL LFGFTLLEAL TVAVVVTFYD
   121  VYIILQAFIL TTTVFFGLTV YTLQSKKDFS KFGAGLFALL WILCLSGFLK FFFYSEIMEL
   181  VLAAAGALLF CGFIIYDTHS LMHKLSPEEY VLAAISLYLD IINLFLHLLR FLEAVNKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMBIM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

liver: 94 nTPM
pancreas: 86 nTPM
kidney: 84 nTPM
stomach: 80 nTPM
adrenal gland: 79 nTPM
parathyroid gland: 79 nTPM

Single-cell type

late primary spermatocytes: 806 nCPM
parietal cells: 393 nCPM
gastric chief cells: 365 nCPM
early spermatids: 280 nCPM
breast lactating cells: 167 nCPM
late spermatids: 154 nCPM

Immune cell

neutrophil: 598 nTPM
total PBMC: 439 nTPM
basophil: 407 nTPM
non-classical monocyte: 389 nTPM
eosinophil: 343 nTPM
intermediate monocyte: 339 nTPM

Brain region

choroid plexus: 74 nTPM
white matter: 60 nTPM
medulla oblongata: 56 nTPM
hypothalamus: 50 nTPM
spinal cord: 47 nTPM
pons: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMBIM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ITPR3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMBIM4 as an antibody target. Whether an autoantibody or antibody against TMBIM4 could matter depends on whether native TMBIM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMBIM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMBIM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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