Seroatlas · Human Serome Atlas

FAIM2

Protein lifeguard 2

Also known as: KIAA0950, LFG, LFG2, LFG2_HUMAN, LIFEGUARD, NMP35, TMBIM2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWQ8
Gene: FAIM2
Ensembl: ENSG00000135472
Chromosome: 12
Canonical length: 316 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Intermediate filaments

OverviewNCBI Gene

Predicted to enable calcium channel activity. Involved in regulation of neuron apoptotic process. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in Golgi membrane and membrane raft. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q9BWQ8|FAIM2
     1  MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG AFPPAPTAVP
    61  LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR VFVRKVYTIL LIQLLVTLAV
   121  VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTVFTLSMA
   181  YLTGMLSSYY NTTSVLLCLG ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI
   241  LAILLPFQYV PWLHAVYAAL GAGVFTLFLA LDTQLLMGNR RHSLSPEEYI FGALNIYLDI
   301  IYIFTFFLQL FGTNRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 309 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 309 nTPM
hypothalamus: 227 nTPM
basal ganglia: 205 nTPM
cerebellum: 203 nTPM
spinal cord: 187 nTPM
hippocampal formation: 185 nTPM

Single-cell type

early spermatids: 190 nCPM
late primary spermatocytes: 180 nCPM
other brain neurons: 149 nCPM
brain inhibitory neurons: 147 nCPM
retinal horizontal cells: 138 nCPM
adrenal medulla cells: 128 nCPM

Immune cell

T-reg: 3 nTPM
gdT-cell: 0.7 nTPM
NK-cell: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM

Brain region

cerebral cortex: 948 nTPM
pons: 679 nTPM
white matter: 661 nTPM
basal ganglia: 587 nTPM
thalamus: 581 nTPM
medulla oblongata: 560 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 1.6
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAIM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAIM2 as an antibody target. Whether an autoantibody or antibody against FAIM2 could matter depends on whether native FAIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAIM2 is annotated at the cell surface, where native FAIM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FAIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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