RPEL repeat

Definition

RPEL repeat (RPxxxEL) containing proteins are found in a wide range of metazoan organisms. RPEL repeats have been shown to be required for unpolymerised actin binding and proteins containing RPEL repeats are able to modify cell shape and/or are important in the regulation of gene expression by the actin cytoskeleton. RPEL repeats can be found in association with the SAP motif, which could be involved in DNA binding [[cite:PMID:12732141], [cite:PMID:15620697]]. Some proteins known to contain RPEL repeats are listed below: Mammalian myocardin, heart-specific serum response factor (SRF) co- activator. Vertebrate myocardin-related transcription factor A (MRTF-A or MAL), a signal-regulated SRF co-activator. Vertebrate myocardin-related transcription factor B (MRTF-B). Mammalian phosphatase and actin regulator 1 to 3.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• MRTFA
• MRTFB
• MYOCD
• PHACTR1
• PHACTR2
• PHACTR3
• PHACTR4