Seroatlas · Human Serome Atlas

PHACTR3

Phosphatase and actin regulator 3

Also known as: C20orf101, PHAR3_HUMAN, PPP1R123

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KR7
Gene: PHACTR3
Ensembl: ENSG00000087495
Chromosome: 20
Canonical length: 559 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>Q96KR7|PHACTR3
     1  MAASEDGSGC LVSRGRSQSD PSVLTDSSAT SSADAGENPD EMDQTPPARP EYLVSGIRTP
    61  PVRRNSKLAT LGRIFKPWKW RKKKNEKLKQ TTSALEKKMA GRQGREELIK KGLLEMMEQD
   121  AESKTCNPDG GPRSVQSEPP TPKSETLTSE DAQPGSPLAT GTDQVSLDKP LSSAAHLDDA
   181  AKMPSASSGE EADAGSLLPT TNELSQALAG ADSLDSPPRP LERSVGQLPS PPLLPTPPPK
   241  ASSKTTKNVT GQATLFQASS MKSADPSLRG QLSTPTGSPH LTTVHRPLPP SRVIEELHRA
   301  LATKHRQDSF QGRESKGSPK KRLDVRLSRT SSVERGKERE EAWSFDGALE NKRTAAKESE
   361  ENKENLIINS ELKDDLLLYQ DEEALNDSII SGTLPRKCKK ELLAVKLRNR PSKQELEDRN
   421  IFPRRTDEER QEIRQQIEMK LSKRLSQRPA VEELERRNIL KQRNDQTEQE ERREIKQRLT
   481  RKLNQRPTVD ELRDRKILIR FSDYVEVAKA QDYDRRADKP WTRLSAADKA AIRKELNEYK
   541  SNEMEVHASS KHLTRFHRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHACTR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

amygdala: 94 nTPM
midbrain: 84 nTPM
hippocampal formation: 82 nTPM
cerebral cortex: 76 nTPM
spinal cord: 71 nTPM
basal ganglia: 68 nTPM

Single-cell type

oligodendrocyte progenitor cells: 502 nCPM
oligodendrocytes: 474 nCPM
astrocytes: 336 nCPM
retinal ganglion cells: 286 nCPM
retinal amacrine cells: 239 nCPM
brain excitatory neurons: 215 nCPM

Immune cell

myeloid DC: 0.4 nTPM
classical monocyte: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 150 nTPM
thalamus: 130 nTPM
basal ganglia: 127 nTPM
amygdala: 123 nTPM
cerebral cortex: 120 nTPM
midbrain: 107 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 0.97
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

actin cytoskeleton organization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHACTR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP1CA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHACTR3 as an antibody target. Whether an autoantibody or antibody against PHACTR3 could matter depends on whether native PHACTR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHACTR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHACTR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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