Seroatlas · Human Serome Atlas

PHACTR2

Phosphatase and actin regulator 2

Also known as: C6orf56, KIAA0680, PHAR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75167
Gene
PHACTR2
Ensembl
ENSG00000112419
Chromosome
6
Canonical length
634 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Plasma membrane

OverviewNCBI Gene

Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in plasma membrane and platelet alpha granule membrane. Implicated in Parkinson's disease and multiple sclerosis. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

634 residues, UniProt reviewed canonical sequence.

>O75167|PHACTR2
     1  MDNAVDGLDK ASIANSDGPT AGSQTPPFKR KGKLSTIGKI FKPWKWRKKK TSDKFRETSA
    61  VLERKISTRQ SREELIRRGV LKELPDQDGD VTVNFENSNG HMIPIGEEST REENVVKSEE
   121  GNGSVSEKTP PLEEQAEDKK ENTENHSETP AAPALPPSAP PKPRPKPKPK KSPVPPKGAT
   181  AGASHKGDEV PPIKKNTKAP GKQAPVPPPK PASRNTTREA AGSSHSKKTT GSKASASPST
   241  SSTSSRPKAS KETVSSKAGT VGTTKGKRKT DKQPITSHLS SDTTTSGTSD LKGEPAETRV
   301  ESFKLEQTVP GAEEQNTGKF KSMVPPPPVA PAPSPLAPPL PLEDQCITAS DTPVVLVSVG
   361  ADLPVSALDP SQLLWAEEPT NRTTLYSGTG LSVNRENAKC FTTKEELGKT VPQLLTPGLM
   421  GESSESFSAS EDEGHREYQA NDSDSDGPIL YTDDEDEDED EDGSGESALA SKIRRRDTLA
   481  IKLGNRPSKK ELEDKNILQR TSEEERQEIR QQIGTKLVRR LSQRPTTEEL EQRNILKQKN
   541  EEEEQEAKME LKRRLSRKLS LRPTVAELQA RRILRFNEYV EVTDSPDYDR RADKPWARLT
   601  PADKAAIRKE LNEFKSTEME VHEESRQFTR FHRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHACTR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 79 nTPM
  • adrenal gland: 23 nTPM
  • esophagus: 18 nTPM
  • choroid plexus: 17 nTPM
  • lung: 15 nTPM
  • thyroid gland: 14 nTPM

Single-cell type

  • choroid plexus epithelial cells: 2,026 nCPM
  • retinal pigment epithelial cells: 878 nCPM
  • adrenal cortex cells: 691 nCPM
  • foveolar cells: 532 nCPM
  • innate lymphoid cells: 354 nCPM
  • sertoli cells: 340 nCPM

Immune cell

  • MAIT T-cell: 12 nTPM
  • eosinophil: 6.4 nTPM
  • T-reg: 5.4 nTPM
  • basophil: 5.2 nTPM
  • memory CD8 T-cell: 4.4 nTPM
  • memory CD4 T-cell: 4 nTPM

Brain region

  • choroid plexus: 354 nTPM
  • thalamus: 50 nTPM
  • pons: 47 nTPM
  • medulla oblongata: 40 nTPM
  • midbrain: 38 nTPM
  • hippocampal formation: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
gnomAD missense Z
0.81
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHACTR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHACTR2 as an antibody target. Whether an autoantibody or antibody against PHACTR2 could matter depends on whether native PHACTR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHACTR2 is annotated at the cell surface, where native PHACTR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PHACTR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PHACTR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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