CobW/HypB/UreG, nucleotide-binding domain

Definition

This domain is found in HypB, a hydrogenase expression/formation protein, and urease accessory protein UreG. Both these proteins contain a P-loop nucleotide binding motif [[cite:PMID:9209019], [cite:PMID:8423137]]. HypB has GTPase activity and is a guanine nucleotide binding protein PMID:8423137. UreG is a GTPase in charge of nucleotide hydrolysis required for activation of the urease enzyme PMID:25846143. Both GTPases are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression PMID:9140970. UreG is required for functional incorporation of the urease nickel metallocentre PMID:1624427. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins PMID:9140970. Other proteins containing this domain include P47K ([swissprot:P31521]), a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, CobW ([swissprot:P29937]), which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans PMID:1655697, and YjiA PMID:14696199. Both CobW and YjiA are members of the metal homeostasis-associated COG0523 family of GTPases PMID:24449932.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• ZNG1A
• ZNG1B
• ZNG1C
• ZNG1E
• ZNG1F