Seroatlas · Human Serome Atlas

CLIC4

Chloride intracellular channel protein 4

Also known as: CLIC4_HUMAN, CLIC4L, DKFZP566G223, H1, huH1, P64H1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y696
Gene
CLIC4
Ensembl
ENSG00000169504
Chromosome
1
Canonical length
253 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Plasma membrane,Centrosome,Calyx,Connecting piece,Principal piece

OverviewNCBI Gene

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q9Y696|CLIC4
     1  MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV VFSVTTVDLK
    61  RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC PPKYLKLSPK HPESNTAGMD
   121  IFAKFSAYIK NSRPEANEAL ERGLLKTLQK LDEYLNSPLP DEIDENSMED IKFSTRKFLD
   181  GNEMTLADCN LLPKLHIVKV VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV
   241  EIAYSDVAKR LTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLIC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
408 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 408 nTPM
  • smooth muscle: 262 nTPM
  • kidney: 240 nTPM
  • endometrium: 189 nTPM
  • heart muscle: 185 nTPM
  • cervix: 156 nTPM

Single-cell type

  • schwann cells: 1,131 nCPM
  • smooth muscle cells: 835 nCPM
  • epicardial cells: 755 nCPM
  • extravillous trophoblasts: 630 nCPM
  • plasma cells: 613 nCPM
  • endometrial stromal cells: 591 nCPM

Immune cell

  • memory B-cell: 14 nTPM
  • naive B-cell: 12 nTPM
  • myeloid DC: 5.6 nTPM
  • classical monocyte: 5.4 nTPM
  • intermediate monocyte: 4.4 nTPM
  • non-classical monocyte: 4 nTPM

Brain region

  • thalamus: 147 nTPM
  • white matter: 140 nTPM
  • medulla oblongata: 109 nTPM
  • basal ganglia: 98 nTPM
  • midbrain: 95 nTPM
  • hypothalamus: 93 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLIC4.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 28 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
0.79
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLIC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLIC4 as an antibody target. Whether an autoantibody or antibody against CLIC4 could matter depends on whether native CLIC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLIC4 is annotated at the cell surface, where native CLIC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLIC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLIC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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