Seroatlas · Human Serome Atlas

CLIC6

Chloride intracellular channel protein 6

Also known as: CLIC1L, CLIC5, CLIC6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96NY7
Gene
CLIC6
Ensembl
ENSG00000159212
Chromosome
21
Canonical length
704 aa
Protein class
Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

704 residues, UniProt reviewed canonical sequence.

>Q96NY7|CLIC6
     1  MAEAAEPEGV APGPQGPPEV PAPLAERPGE PGAAGGEAEG PEGSEGAEEA PRGAAAVKEA
    61  GGGGPDRGPE AEARGTRGAH GETEAEEGAP EGAEVPQGGE ETSGAQQVEG ASPGRGAQGE
   121  PRGEAQREPE DSAAPERQEE AEQRPEVPEG SASGEAGDSV DAEGPLGDNI EAEGPAGDSV
   181  EAEGRVGDSV DAEGPAGDSV DAEGPLGDNI QAEGPAGDSV DAEGRVGDSV DAEGPAGDSV
   241  DAEGRVGDSV EAGDPAGDGV EAGVPAGDSV EAEGPAGDSM DAEGPAGRAR RVSGEPQQSG
   301  DGSLSPQAEA IEVAAGESAG RSPGELAWDA AEEAEVPGVK GSEEAAPGDA RADAGEDRVG
   361  DGPQQEPGED EERRERSPEG PREEEAAGGE EESPDSSPHG EASRGAAEPE AQLSNHLAEE
   421  GPAEGSGEAA RVNGRREDGE ASEPRALGQE HDITLFVKVK LTALGCSRIA IKKYLRAGYD
   481  GESIGNCPFS QRLFMILWLK GVIFNVTTVD LKRKPADLQN LAPGTNPPFM TFDGEVKTDV
   541  NKIEEFLEEK LAPPRYPKLG TQHPESNSAG NDVFAKFSAF IKNTKKDANE IHEKNLLKAL
   601  RKLDNYLNSP LPDEIDAYST EDVTVSGRKF LDGDELTLAD CNLLPKLHII KIVAKKYRDF
   661  EFPSEMTGIW RYLNNAYARD EFTNTCPADQ EIEHAYSDVA KRMK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLIC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
410 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 410 nTPM
  • stomach: 127 nTPM
  • parathyroid gland: 27 nTPM
  • salivary gland: 24 nTPM
  • cervix: 15 nTPM
  • thyroid gland: 12 nTPM

Single-cell type

  • choroid plexus epithelial cells: 2,259 nCPM
  • parietal cells: 1,434 nCPM
  • retinal pigment epithelial cells: 857 nCPM
  • respiratory ciliated cells: 339 nCPM
  • transitional alveolar cells: 201 nCPM
  • ependymal cells: 199 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 506 nTPM
  • hippocampal formation: 25 nTPM
  • midbrain: 11 nTPM
  • thalamus: 9.7 nTPM
  • medulla oblongata: 7.8 nTPM
  • cerebellum: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLIC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLIC6 as an antibody target. Whether an autoantibody or antibody against CLIC6 could matter depends on whether native CLIC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLIC6 is annotated at the cell surface, where native CLIC6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLIC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLIC6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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