Seroatlas · Human Serome Atlas

PTCD2

Pentatricopeptide repeat-containing protein 2, mitochondrial

Also known as: FLJ12598, PTCD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WV60
Gene: PTCD2
Ensembl: ENSG00000049883
Chromosome: 5
Canonical length: 388 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in mitochondrion organization and regulation of mRNA processing. Predicted to act upstream of or within several processes, including liver development; muscle cell development; and ventricular cardiac muscle tissue morphogenesis. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q8WV60|PTCD2
     1  MVRDSMAAAF RPSNRVLLQA LQILVYPGVG GSGSVSCRCP LGAKRYLLTD NVVKLKEFQQ
    61  KKVAVACNLS GTKETYFRNL KKKLTQNKLI LKGELITLLH LCESRDHVEL AKNVIYRYHA
   121  ENKNFTLGEY KFGPLFVRLC YELDLEESAV ELMKDQHLRG FFSDSTSFNI LMDMLFIKGK
   181  YKSALQVLIE MKNQDVKFTK DTYVLAFAIC YKLNSPESFK ICTTLREEAL LKGEILSRRA
   241  SCFAVALALN QNEMAKAVSI FSQIMNPESI ACINLNIIIH IQSNMLENLI KTLKNAAEGN
   301  LSKFVKRHVF SEEVLAKVRE KVKDVPALVA KFDEIYGTLH ITGQVTTDSL DAVLCHTPRD
   361  RKSHTLLLNK RMVSRRTFQP LSQSLLAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTCD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

tongue: 13 nTPM
choroid plexus: 11 nTPM
skeletal muscle: 8.2 nTPM
heart muscle: 6.9 nTPM
parathyroid gland: 4.5 nTPM
adrenal gland: 4.4 nTPM

Single-cell type

choroid plexus epithelial cells: 63 nCPM
cone photoreceptor cells: 33 nCPM
rod photoreceptor cells: 27 nCPM
cytotrophoblasts: 25 nCPM
astrocytes: 24 nCPM
ependymal cells: 24 nCPM

Immune cell

NK-cell: 3.2 nTPM
T-reg: 2.1 nTPM
myeloid DC: 1.9 nTPM
naive CD8 T-cell: 1.9 nTPM
naive B-cell: 1.6 nTPM
naive CD4 T-cell: 1.5 nTPM

Brain region

choroid plexus: 10 nTPM
white matter: 6.7 nTPM
pons: 6.5 nTPM
midbrain: 5.8 nTPM
thalamus: 5.7 nTPM
cerebellum: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Pentatricopeptide repeat
Tetratricopeptide-like helical domain superfamily
mS27/PTCD2
Mitochondrial 28S ribosomal protein S27
Pentatricopeptide repeat-containing protein 2, mitochondrial

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTCD2 as an antibody target. Whether an autoantibody or antibody against PTCD2 could matter depends on whether native PTCD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTCD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTCD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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