Bile acid:sodium symporter/arsenical resistance protein Acr3
IPR002657
Definition
This family of proteins are found both in prokaryotes and eukaryotes. They are related to the human bile acid:sodium symporters (TC 2.A.28), which are transmembrane proteins functioning in the liver in the uptake of bile acids from portal blood plasma, a process mediated by the co-transport of Na+ PMID:1961729. This entry also includes members of the ACR3 family of arsenite (As(III)) permeases, which confer resistance to arsenic by extrusion from cells PMID:19494117. They exist in prokaryotes and eukaryotes (lower plants and fungi) [[cite:PMID:20530755], [cite:PMID:24291645]]. The ACR3 permeases have ten-transmembrane span topology PMID:18088595. Corynebacterium glutamicum has three Acr3 proteins, CgAcr3-1, CgAcr3-2, and CgAcr3-3. CgAcr3-1 is thought to be an antiporter that catalyses arsenite-proton exchange PMID:22102279. The Shewanella oneidensis Acr3 is not able to transport As(III) and confers resistance only to arsenate (As(V)) PMID:19039703, whereas the Acr3 orthologue from Synechocystis mediates tolerance to As(III), As(V) and antimonite (Sb(III)) PMID:12949088. In budding yeast, overexpression of the Acr3 gene confers an arsenite- but not an arsenate-resistance phenotype PMID:9234670. Saccharomyces cerevisiae Acr3 is a plasma membrane metalloid/H+ antiporter that transports arsenite and antimonite PMID:21447319.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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