Seroatlas · Human Serome Atlas

SLC10A6

Sodium-dependent organic anion transporter

Also known as: SOAT, SOAT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KNW5
Gene: SLC10A6
Ensembl: ENSG00000145283
Chromosome: 4
Canonical length: 377 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable bile acid:sodium symporter activity. Predicted to be involved in bile acid and bile salt transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q3KNW5|SLC10A6
     1  MRANCSSSSA CPANSSEEEL PVGLEVHGNL ELVFTVVSTV MMGLLMFSLG CSVEIRKLWS
    61  HIRRPWGIAV GLLCQFGLMP FTAYLLAISF SLKPVQAIAV LIMGCCPGGT ISNIFTFWVD
   121  GDMDLSISMT TCSTVAALGM MPLCIYLYTW SWSLQQNLTI PYQNIGITLV CLTIPVAFGV
   181  YVNYRWPKQS KIILKIGAVV GGVLLLVVAV AGVVLAKGSW NSDITLLTIS FIFPLIGHVT
   241  GFLLALFTHQ SWQRCRTISL ETGAQNIQMC ITMLQLSFTA EHLVQMLSFP LAYGLFQLID
   301  GFLIVAAYQT YKRRLKNKHG KKNSGCTEVC HTRKSTSSRE TNAFLEVNEE GAITPGPPGP
   361  MDCHRALEPV GHITSCE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC10A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

skin: 12 nTPM
esophagus: 8.5 nTPM
adipose tissue: 4.8 nTPM
vagina: 4.3 nTPM
testis: 3.7 nTPM
cervix: 3.4 nTPM

Single-cell type

late spermatids: 322 nCPM
suprabasal keratinocytes: 117 nCPM
early spermatids: 94 nCPM
esophageal apical cells: 80 nCPM
basal keratinocytes: 51 nCPM
endometrial luminal cells: 44 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 2.4 nTPM
white matter: 1.7 nTPM
hypothalamus: 1.2 nTPM
pons: 1 nTPM
basal ganglia: 0.8 nTPM
cerebral cortex: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

bile acid and bile salt transport
transmembrane transport
sodium-dependent organic anion transport

Molecular functions

bile acid:sodium symporter activity
sodium-dependent organic anion transmembrane transporter activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC10A6 as an antibody target. Whether an autoantibody or antibody against SLC10A6 could matter depends on whether native SLC10A6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC10A6 is annotated at the cell surface, where native SLC10A6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC10A6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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