Seroatlas · Human Serome Atlas

SLC10A1

Hepatic sodium/bile acid cotransporter

Also known as: NTCP, NTCP_HUMAN, NTCP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14973
Gene
SLC10A1
Ensembl
ENSG00000100652
Chromosome
14
Canonical length
349 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q14973|SLC10A1
     1  MEAHNASAPF NFTLPPNFGK RPTDLALSVI LVFMLFFIML SLGCTMEFSK IKAHLWKPKG
    61  LAIALVAQYG IMPLTAFVLG KVFRLKNIEA LAILVCGCSP GGNLSNVFSL AMKGDMNLSI
   121  VMTTCSTFCA LGMMPLLLYI YSRGIYDGDL KDKVPYKGIV ISLVLVLIPC TIGIVLKSKR
   181  PQYMRYVIKG GMIIILLCSV AVTVLSAINV GKSIMFAMTP LLIATSSLMP FIGFLLGYVL
   241  SALFCLNGRC RRTVSMETGC QNVQLCSTIL NVAFPPEVIG PLFFFPLLYM IFQLGEGLLL
   301  IAIFWCYEKF KTPKDKTKMI YTAATTEETI PGALGNGTYK GEDCSPCTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC10A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
399 nTPM

Expression across tissuesHPA

Tissue

  • liver: 399 nTPM
  • bone marrow: 0.3 nTPM
  • gallbladder: 0.3 nTPM
  • cerebellum: 0.1 nTPM
  • colon: 0.1 nTPM
  • esophagus: 0.1 nTPM

Single-cell type

  • hepatocytes: 217 nCPM
  • epicardial cells: 109 nCPM
  • breast myoepithelial cells: 67 nCPM
  • thymocytes: 64 nCPM
  • innate lymphoid cells: 46 nCPM
  • pdcs: 45 nCPM

Immune cell

  • neutrophil: 0.5 nTPM
  • eosinophil: 0.3 nTPM
  • gdT-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • cerebellum: 7.8 nTPM
  • cerebral cortex: 5 nTPM
  • hippocampal formation: 4 nTPM
  • hypothalamus: 3.6 nTPM
  • basal ganglia: 3.4 nTPM
  • medulla oblongata: 3.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC10A1.

Disease | AllUniProt

Conditions SLC10A1 is implicated in, by any mechanism.

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 177 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • SLC10A1-related disorder
  • Hypercholanemia, familial, 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.98
gnomAD pLI
0
gnomAD missense Z
-1.98
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC10A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC10A1 as an antibody target. Whether an autoantibody or antibody against SLC10A1 could matter depends on whether native SLC10A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC10A1 is annotated at the cell surface, where native SLC10A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC10A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC10A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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