Seroatlas · Human Serome Atlas

SLC10A4

Sodium/bile acid cotransporter 4

Also known as: MGC29802, NTCP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EP9
Gene: SLC10A4
Ensembl: ENSG00000145248
Chromosome: 4
Canonical length: 437 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable bile acid:sodium symporter activity. Predicted to be involved in bile acid and bile salt transport and regulation of neurotransmitter loading into synaptic vesicle. Predicted to act upstream of or within adult behavior and response to xenobiotic stimulus. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including dopaminergic synapse; serotonergic synapse; and synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q96EP9|SLC10A4
     1  MDGNDNVTLL FAPLLRDNYT LAPNASSLGP GTDLALAPAS SAGPGPGLSL GPGPSFGFSP
    61  GPTPTPEPTT SGLAGGAASH GPSPFPRPWA PHALPFWDTP LNHGLNVFVG AALCITMLGL
   121  GCTVDVNHFG AHVRRPVGAL LAALCQFGLL PLLAFLLALA FKLDEVAAVA VLLCGCCPGG
   181  NLSNLMSLLV DGDMNLSIIM TISSTLLALV LMPLCLWIYS WAWINTPIVQ LLPLGTVTLT
   241  LCSTLIPIGL GVFIRYKYSR VADYIVKVSL WSLLVTLVVL FIMTGTMLGP ELLASIPAAV
   301  YVIAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL AFPPQFIGSM
   361  YMFPLLYALF QSAEAGIFVL IYKMYGSEML HKRDPLDEDE DTDISYKKLK EEEMADTSYG
   421  TVKAENIIMM ETAQTSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC10A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

midbrain: 11 nTPM
pituitary gland: 5 nTPM
hypothalamus: 3.8 nTPM
adrenal gland: 2.6 nTPM
basal ganglia: 2.6 nTPM
blood vessel: 1.9 nTPM

Single-cell type

other brain neurons: 39 nCPM
thyrotrophs: 34 nCPM
erythrocyte progenitors: 19 nCPM
salivary myoepithelial cells: 9.4 nCPM
brain inhibitory neurons: 9.3 nCPM
oocytes: 9.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 80 nTPM
pons: 51 nTPM
hypothalamus: 20 nTPM
medulla oblongata: 19 nTPM
cerebral cortex: 15 nTPM
thalamus: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.03
gnomAD missense Z: 1
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC10A4 as an antibody target. Whether an autoantibody or antibody against SLC10A4 could matter depends on whether native SLC10A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC10A4 is annotated at the cell surface, where native SLC10A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC10A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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