Seroatlas · Human Serome Atlas

SLC10A3

P3 protein

Also known as: DXS253E, P3, P3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P09131
Gene: SLC10A3
Ensembl: ENSG00000126903
Chromosome: X
Canonical length: 477 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Intermediate filaments

OverviewNCBI Gene

This gene maps to a GC-rich region of the X chromosome and was identified by its proximity to a CpG island. It is thought to be a housekeeping gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>P09131|SLC10A3
     1  MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL STAGGHTVPP
    61  TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA PGPMLRVTSL DTEVLTIKNV
   121  SAITWGGGGG FVVSIHSGLA GLAPLHIQLV DAHEAPPTLI EERRDFCIKV SPAEDTPATL
   181  SADLAHFSEN PILYLLLPLI FVNKCSFGCK VELEVLKGLM QSPQPMLLGL LGQFLVMPLY
   241  AFLMAKVFML PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFL STVAATGFLP
   301  LSSAIYSRLL SIHETLHVPI SKILGTLLFI AIPIAVGVLI KSKLPKFSQL LLQVVKPFSF
   361  VLLLGGLFLA YRMGVFILAG IRLPIVLVGI TVPLVGLLVG YCLATCLKLP VAQRRTVSIE
   421  VGVQNSLLAL AMLQLSLRRL QADYASQAPF IVALSGTSEM LALVIGHFIY SSLFPVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC10A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

skin: 41 nTPM
ovary: 39 nTPM
blood vessel: 37 nTPM
bone marrow: 32 nTPM
esophagus: 30 nTPM
urinary bladder: 29 nTPM

Single-cell type

platelets: 147 nCPM
syncytiotrophoblasts: 119 nCPM
extravillous trophoblasts: 80 nCPM
esophageal apical cells: 78 nCPM
migrating cytotrophoblasts: 64 nCPM
epididymal principal cells: 60 nCPM

Immune cell

basophil: 219 nTPM
eosinophil: 21 nTPM
gdT-cell: 13 nTPM
MAIT T-cell: 9.6 nTPM
plasmacytoid DC: 9.5 nTPM
memory CD8 T-cell: 9.2 nTPM

Brain region

thalamus: 14 nTPM
white matter: 12 nTPM
medulla oblongata: 12 nTPM
pons: 12 nTPM
spinal cord: 11 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.81
gnomAD missense Z: 1.22
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

bile acid:sodium symporter activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC10A3 as an antibody target. Whether an autoantibody or antibody against SLC10A3 could matter depends on whether native SLC10A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC10A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC10A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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