Seroatlas · Human Serome Atlas

SLC10A5

Sodium/bile acid cotransporter 5

Also known as: NTCP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5PT55
Gene: SLC10A5
Ensembl: ENSG00000253598
Chromosome: 8
Canonical length: 438 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane

OverviewNCBI Gene

Predicted to enable bile acid:sodium symporter activity. Predicted to be involved in bile acid and bile salt transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>Q5PT55|SLC10A5
     1  MIRKLFIVLL LLLVTIEEAR MSSLSFLNIE KTEILFFTKT EETILVSSSY ENKRPNSSHL
    61  FVKIEDPKIL QMVNVAKKIS SDATNFTINL VTDEEGETNV TIQLWDSEGR QERLIEEIKN
   121  VKVKVLKQKD SLLQAPMHID RNILMLILPL ILLNKCAFGC KIELQLFQTV WKRPLPVILG
   181  AVTQFFLMPF CGFLLSQIVA LPEAQAFGVV MTCTCPGGGG GYLFALLLDG DFTLAILMTC
   241  TSTLLALIMM PVNSYIYSRI LGLSGTFHIP VSKIVSTLLF ILVPVSIGIV IKHRIPEKAS
   301  FLERIIRPLS FILMFVGIYL TFTVGLVFLK TDNLEVILLG LLVPALGLLF GYSFAKVCTL
   361  PLPVCKTVAI ESGMLNSFLA LAVIQLSFPQ SKANLASVAP FTVAMCSGCE MLLIILVYKA
   421  KKRCIFFLQD KRKRNFLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC10A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

liver: 11 nTPM
small intestine: 3.7 nTPM
rectum: 3.4 nTPM
stomach: 3.3 nTPM
duodenum: 3 nTPM
colon: 2.7 nTPM

Single-cell type

foveolar cells: 11 nCPM
esophageal apical cells: 6.9 nCPM
enterocytes: 6.6 nCPM
proximal tubule cells: 5.7 nCPM
colonocytes: 5.1 nCPM
hematopoietic stem cells: 3.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 4.8 nTPM
cerebral cortex: 4 nTPM
hypothalamus: 3.1 nTPM
basal ganglia: 2.9 nTPM
hippocampal formation: 2.7 nTPM
white matter: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC10A5 as an antibody target. Whether an autoantibody or antibody against SLC10A5 could matter depends on whether native SLC10A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC10A5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC10A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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