Seroatlas · Human Serome Atlas

ZRANB2

Zinc finger Ran-binding domain-containing protein 2

Also known as: ZIS, ZIS1, ZIS2, ZNF265, ZRAB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95218
Gene: ZRANB2
Ensembl: ENSG00000132485
Chromosome: 1
Canonical length: 330 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>O95218|ZRANB2
     1  MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT EIGKTLAEKS
    61  RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT GYGGGFNERE NVEYIEREES
   121  DGEYDEFGRK KKKYRGKAVG PASILKEVED KESEGEEEDE DEDLSKYKLD EDEDEDDADL
   181  SKYNLDASEE EDSNKKKSNR RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR
   241  SRSSSRERSR SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERNRKRSRS RSSSSGDRKK
   301  RRTRSRSPER RHRSSSGSSH SGSRSSSKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZRANB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 67 nTPM
endometrium: 66 nTPM
epididymis: 64 nTPM
cerebellum: 62 nTPM
lymph node: 58 nTPM
retina: 58 nTPM

Single-cell type

lactotrophs: 677 nCPM
somatotrophs: 667 nCPM
pituicytes/fscs: 565 nCPM
leydig cells: 548 nCPM
corticotrophs: 530 nCPM
sertoli cells: 527 nCPM

Immune cell

basophil: 99 nTPM
plasmacytoid DC: 74 nTPM
memory B-cell: 69 nTPM
naive B-cell: 63 nTPM
naive CD4 T-cell: 61 nTPM
MAIT T-cell: 51 nTPM

Brain region

white matter: 77 nTPM
choroid plexus: 77 nTPM
cerebellum: 75 nTPM
cerebral cortex: 74 nTPM
medulla oblongata: 66 nTPM
pons: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 1.68
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RanBP2-type
Zinc finger, RanBP2-type superfamily
Zn-finger in Ran binding protein and others
Zinc finger Ran-binding domain-containing protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZRANB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZRANB2 as an antibody target. Whether an autoantibody or antibody against ZRANB2 could matter depends on whether native ZRANB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZRANB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZRANB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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