Seroatlas · Human Serome Atlas

RIDA

2-iminobutanoate/2-iminopropanoate deaminase

Also known as: HRSP12, P14.5, PSP, RIDA_HUMAN, UK114

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52758
Gene: RIDA
Ensembl: ENSG00000132541
Chromosome: 8
Canonical length: 137 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Quaternary structure: Homotrimer

OverviewNCBI Gene

Enables mRNA binding activity. Involved in mRNA catabolic process and mRNA destabilization. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>P52758|RIDA
     1  MSSLIRRVIS TAKAPGAIGP YSQAVLVDRT IYISGQIGMD PSSGQLVSGG VAEEAKQALK
    61  NMGEILKAAG CDFTNVVKTT VLLADINDFN TVNEIYKQYF KSNFPARAAY QVAALPKGSR
   121  IEIEAVAIQG PLTTASL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIDA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 1,435 nTPM

Expression across tissuesHPA

Tissue

liver: 1,435 nTPM
kidney: 462 nTPM
basal ganglia: 133 nTPM
midbrain: 131 nTPM
amygdala: 108 nTPM
cerebral cortex: 102 nTPM

Single-cell type

hepatocytes: 954 nCPM
cholangiocytes: 194 nCPM
epididymal efferent duct absorptive cells: 138 nCPM
parietal cells: 76 nCPM
esophageal suprabasal cells: 70 nCPM
proximal tubule cells: 65 nCPM

Immune cell

T-reg: 14 nTPM
memory B-cell: 14 nTPM
naive CD8 T-cell: 13 nTPM
naive CD4 T-cell: 12 nTPM
naive B-cell: 12 nTPM
myeloid DC: 11 nTPM

Brain region

thalamus: 50 nTPM
midbrain: 44 nTPM
basal ganglia: 41 nTPM
medulla oblongata: 40 nTPM
cerebellum: 40 nTPM
hypothalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0.07
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid metabolic process
mRNA catabolic process
mRNA destabilization
negative regulation of translation
L-threonine catabolic process to glycine

Molecular functions

deaminase activity
mRNA binding
RNA binding
2-iminobutanoate deaminase activity
2-iminopropanoate deaminase activity
RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism

Cellular components

Protein domainsUniProt · Pfam · InterPro

RidA family
YjgF/YER057c/UK114 family
RidA, conserved site
RutC-like superfamily
Endoribonuclease L-PSP

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIDA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

YTHDF2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIDA as an antibody target. Whether an autoantibody or antibody against RIDA could matter depends on whether native RIDA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIDA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIDA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...