Seroatlas · Human Serome Atlas

FAF2

FAS-associated factor 2

Also known as: ETEA, FAF2_HUMAN, KIAA0887, UBXD8, UBXN3B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CS3
Gene: FAF2
Ensembl: ENSG00000113194
Chromosome: 5
Canonical length: 445 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum,Lipid droplets

OverviewNCBI Gene

The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q96CS3|FAF2
     1  MAAPEERDLT QEQTEKLLQF QDLTGIESMD QCRHTLEQHN WNIEAAVQDR LNEQEGVPSV
    61  FNPPPSRPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM LPFRFTYYTI LDIFRFALRF
   121  IRPDPRSRVT DPVGDIVSFM HSFEEKYGRA HPVFYQGTYS QALNDAKREL RFLLVYLHGD
   181  DHQDSDEFCR NTLCAPEVIS LINTRMLFWA CSTNKPEGYR VSQALRENTY PFLAMIMLKD
   241  RRMTVVGRLE GLIQPDDLIN QLTFIMDANQ TYLVSERLER EERNQTQVLR QQQDEAYLAS
   301  LRADQEKERK KREERERKRR KEEEVQQQKL AEERRRQNLQ EEKERKLECL PPEPSPDDPE
   361  SVKIIFKLPN DSRVERRFHF SQSLTVIHDF LFSLKESPEK FQIEANFPRR VLPCIPSEEW
   421  PNPPTLQEAG LSHTEVLFVQ DLTDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 23 nTPM
thymus: 22 nTPM
retina: 21 nTPM
bone marrow: 20 nTPM
testis: 20 nTPM
liver: 20 nTPM

Single-cell type

myonuclei: 166 nCPM
neutrophils: 160 nCPM
choroid plexus epithelial cells: 103 nCPM
somatotrophs: 101 nCPM
syncytiotrophoblasts: 101 nCPM
early primary spermatocytes: 99 nCPM

Immune cell

non-classical monocyte: 12 nTPM
T-reg: 9.9 nTPM
NK-cell: 9.2 nTPM
basophil: 9.1 nTPM
MAIT T-cell: 8.3 nTPM
myeloid DC: 8 nTPM

Brain region

choroid plexus: 33 nTPM
hypothalamus: 26 nTPM
pons: 26 nTPM
cerebellum: 26 nTPM
midbrain: 25 nTPM
thalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 2.52
DepMap mean gene effect: -0.45
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAF2 as an antibody target. Whether an autoantibody or antibody against FAF2 could matter depends on whether native FAF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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