Seroatlas · Human Serome Atlas

ZAR1L

Protein ZAR1-like

Also known as: Z3CXXC7, ZAR1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NP61
Gene: ZAR1L
Ensembl: ENSG00000189167
Chromosome: 13
Canonical length: 321 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

This gene encodes a member of the ZAR1 family that is predominantly expressed in oocytes and early embryos. The protein may function as an RNA regulator in early embryos. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>A6NP61|ZAR1L
     1  MERFVRVPYG LYQGYGSTVP LGQPGLSGHK QPDWRQNMGP PTFLARPGLL VPANAPDYCI
    61  DPYKRAQLKA ILSQMNPSLS PRLCKPNTKE VGVQVSPRVD KAVQCSLGPR TLSSCSPWDG
   121  RDPQEPLPAC GVTSPATGRR GLIRLRRDGD EAESKALPGP AEASQPQPPS RRSGADRQEE
   181  PGQLEESGEK DAPCPQETKS KQVPGDAASE PLRRPNFQFL EPKYGYFHCK DCKTRWESAY
   241  VWCISGTNKV YFKQLCCKCQ KSFNPYRVEA IQCQTCSKSH CSCPQKKRHI DLRRPHRQEL
   301  CGRCKDKRFS CGNIYSFKYV M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZAR1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

testis: 0.7 nTPM
bone marrow: 0.1 nTPM
lymph node: 0.1 nTPM
ovary: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

oocytes: 55 nCPM
paneth cells: 3.9 nCPM
cdc: 2.5 nCPM
late primary spermatocytes: 2.5 nCPM
undifferentiated spermatogonia: 2.5 nCPM
early primary spermatocytes: 2.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.1
gnomAD missense Z: 1.69
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZAR1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

YBX2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZAR1L as an antibody target. Whether an autoantibody or antibody against ZAR1L could matter depends on whether native ZAR1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZAR1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZAR1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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