Seroatlas · Human Serome Atlas

ZAR1

Zygote arrest protein 1

Also known as: Z3CXXC6, ZAR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SH2
Gene: ZAR1
Ensembl: ENSG00000182223
Chromosome: 4
Canonical length: 424 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This maternal effect gene is oocyte-specific and encodes a protein that is thought to function in the initiation of embryogenesis. A similar protein in mouse is required for female fertility. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>Q86SH2|ZAR1
     1  MAALGDEVLD GYVFPACPPC SYRYPYPAAT KGKGAAGGSW QQRGRGCLPA SSPCSAGAAS
    61  LSFPGCGRLT AAEYFDSYQR ERLMALLAQV GPGLGPRARR AGSCDVAVQV SPRIDAAVQC
   121  SLGRRTLQRR ARDPESPAGP GAEGTTGGGS FSQQPSRRGL EQGSPQNGAP RPMRFPRTVA
   181  VYSPLALRRL TAFLEGPGPA AGEQRSGASD GERGPPPARL QGPEEGEVWT KKAPRRPQSD
   241  DDGEAQAAVR ASWEQPADGP ELPPREAQEG EAAPRSALRS PGQPPSAGRA RDGGDGREAA
   301  VAGEGPSPRS PELGKERLRF QFLEQKYGYY HCKDCNIRWE SAYVWCVQGT NKVYFKQFCR
   361  TCQKSYNPYR VEDITCQSCK QTRCSCPVKL RHVDPKRPHR QDLCGRCKGK RLSCDSTFSF
   421  KYII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

testis: 1.3 nTPM
ovary: 0.9 nTPM
midbrain: 0.6 nTPM
bone marrow: 0.3 nTPM
basal ganglia: 0.2 nTPM
salivary gland: 0.2 nTPM

Single-cell type

oocytes: 115 nCPM
late spermatids: 11 nCPM
early spermatids: 5 nCPM
thyrotrophs: 5 nCPM
other brain neurons: 2.3 nCPM
undifferentiated spermatogonia: 1.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 7 nTPM
cerebral cortex: 3.3 nTPM
hypothalamus: 2.9 nTPM
basal ganglia: 1.6 nTPM
white matter: 1.3 nTPM
pons: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZAR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

YBX2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZAR1 as an antibody target. Whether an autoantibody or antibody against ZAR1 could matter depends on whether native ZAR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZAR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZAR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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