USP12
Ubiquitin carboxyl-terminal hydrolase 12
Also known as: UBP12_HUMAN, USP12L1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75317
- Gene
- USP12
- Ensembl
- ENSG00000152484
- Chromosome
- 13
- Canonical length
- 370 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Enables cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in protein deubiquitination. Located in cytoplasm; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
370 residues, UniProt reviewed canonical sequence.
>O75317|USP12
1 MEILMTVSKF ASICTMGANA SALEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC
61 RPFREKVLAY KSQPRKKESL LTCLADLFHS IATQKKKVGV IPPKKFITRL RKENELFDNY
121 MQQDAHEFLN YLLNTIADIL QEERKQEKQN GRLPNGNIDN ENNNSTPDPT WVHEIFQGTL
181 TNETRCLTCE TISSKDEDFL DLSVDVEQNT SITHCLRGFS NTETLCSEYK YYCEECRSKQ
241 EAHKRMKVKK LPMILALHLK RFKYMDQLHR YTKLSYRVVF PLELRLFNTS GDATNPDRMY
301 DLVAVVVHCG SGPNRGHYIA IVKSHDFWLL FDDDIVEKID AQAIEEFYGL TSDISKNSES
361 GYILFYQSRDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against USP12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 71 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 71 nTPM
- retina: 35 nTPM
- colon: 34 nTPM
- liver: 33 nTPM
- lymph node: 27 nTPM
- tonsil: 25 nTPM
Single-cell type
- epicardial cells: 382 nCPM
- monocytes: 280 nCPM
- ocular epithelial cells: 229 nCPM
- cdc: 211 nCPM
- b-cells: 209 nCPM
- platelets: 201 nCPM
Immune cell
- eosinophil: 2.2 nTPM
- naive B-cell: 1.6 nTPM
- T-reg: 1.4 nTPM
- memory B-cell: 1.2 nTPM
- plasmacytoid DC: 1.1 nTPM
- MAIT T-cell: 0.9 nTPM
Brain region
- midbrain: 48 nTPM
- hippocampal formation: 45 nTPM
- thalamus: 43 nTPM
- hypothalamus: 42 nTPM
- basal ganglia: 40 nTPM
- cerebral cortex: 40 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.32
- gnomAD pLI
- 0.97
- gnomAD missense Z
- 2.82
- DepMap mean gene effect
- -0.16
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of USP12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads USP12 as an antibody target. Whether an autoantibody or antibody against USP12 could matter depends on whether native USP12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
USP12 is annotated at the cell surface, where native USP12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label USP12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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