Seroatlas · Human Serome Atlas

RAD51AP1

RAD51-associated protein 1

Also known as: PIR51, R51A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96B01
Gene: RAD51AP1
Ensembl: ENSG00000111247
Chromosome: 12
Canonical length: 352 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables DNA binding activity and RNA binding activity. Involved in DNA repair; cellular response to ionizing radiation; and positive regulation of DNA recombination. Located in chromatin and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q96B01|RAD51AP1
     1  MVRPVRHKKP VNYSQFDHSD SDDDFVSATV PLNKKSRTAP KELKQDKPKP NLNNLRKEEI
    61  PVQEKTPKKR LPEGTFSIPA SAVPCTKMAL DDKLYQRDLE VALALSVKEL PTVTTNVQNS
   121  QDKSIEKHGS SKIETMNKSP HISNCSVASD YLDLDKITVE DDVGGVQGKR KAASKAAAQQ
   181  RKILLEGSDG DSANDTEPDF APGEDSEDDS DFCESEDNDE DFSMRKSKVK EIKKKEVKVK
   241  SPVEKKEKKS KSKCNALVTS VDSAPAAVKS ESQSLPKKVS LSSDTTRKPL EIRSPSAESK
   301  KPKWVPPAAS GGSRSSSSPL VVVSVKSPNQ SLRLGLSRLA RVKPLHPNAT ST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAD51AP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 16 nTPM
thymus: 13 nTPM
lymph node: 8.3 nTPM
tonsil: 7.4 nTPM
rectum: 6.1 nTPM
testis: 5.9 nTPM

Single-cell type

late spermatids: 121 nCPM
erythrocyte progenitors: 79 nCPM
oocytes: 69 nCPM
monocyte progenitors: 65 nCPM
hofbauer cells: 65 nCPM
early spermatids: 59 nCPM

Immune cell

plasmacytoid DC: 7 nTPM
naive B-cell: 3.4 nTPM
memory B-cell: 3.1 nTPM
intermediate monocyte: 2.3 nTPM
non-classical monocyte: 2 nTPM
NK-cell: 1.4 nTPM

Brain region

white matter: 0.9 nTPM
pons: 0.8 nTPM
spinal cord: 0.8 nTPM
basal ganglia: 0.7 nTPM
medulla oblongata: 0.7 nTPM
midbrain: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.01
gnomAD missense Z: 0.47
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAD51AP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAD51AP1 as an antibody target. Whether an autoantibody or antibody against RAD51AP1 could matter depends on whether native RAD51AP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAD51AP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAD51AP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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