VIP

Protein identityUniProt · HPA

UniProt accession

P01282

Gene

VIP

Ensembl

ENSG00000146469

Chromosome

6

Canonical length

170 aa

Protein class

Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Endoplasmic reticulum

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>P01282|VIP
     1  MDTRNKAQLL VLLTLLSVLF SQTSAWPLYR APSALRLGDR IPFEGANEPD QVSLKEDIDM
    61  LQNALAENDT PYYDVSRNAR HADGVFTSDF SKLLGQLSAK KYLESLMGKR VSSNISEDPV
   121  PVKRHSDAVF TDNYTRLRKQ MAVKKYLNSI LNGKRSSEGE SPDFPEELEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

147 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VIP.

Disease | AutoantibodyPubMed

Conditions in which antibodies against VIP are reported. Each links to that disease's full target list.

Showing 0 of 1 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for VIP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.41

gnomAD pLI

0

gnomAD missense Z

0.29

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• body fluid secretion
• G protein-coupled receptor signaling pathway
• mRNA stabilization
• positive regulation of cAMP/PKA signal transduction
• positive regulation of cell population proliferation
• positive regulation of protein catabolic process
• prolactin secretion
• regulation of protein localization
• epinephrine secretion

Molecular functions

• hormone activity
• neuropeptide hormone activity
• peptide hormone receptor binding
• type 1 vasoactive intestinal polypeptide receptor binding
• type 2 vasoactive intestinal polypeptide receptor binding

Cellular components

• extracellular region
• extracellular space
• neuron projection

Protein domainsUniProt · Pfam · InterPro

• Glucagon/GIP/secretin/VIP
• VIP/GHRH-like
• Peptide hormone

KeywordsUniProt

• Amidation
• Cleavage on pair of basic residues
• Hormone
• Phosphoprotein
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of VIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• VIPR2
• VIPR1