Seroatlas · Human Serome Atlas

UNC5CL

UNC5C-like protein

Also known as: MGC34763, UN5CL_HUMAN, ZUD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IV45
Gene
UNC5CL
Ensembl
ENSG00000124602
Chromosome
6
Canonical length
518 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome,Cytosol

OverviewNCBI Gene

Enables peptidase activity. Acts upstream of or within positive regulation of JNK cascade and positive regulation of canonical NF-kappaB signal transduction. Located in centrosome; cytosol; and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q8IV45|UNC5CL
     1  MCPQESSFQP SQFLLLVGVP VASVLLLAQC LRWHCPRRLL GACWTLNGQE EPVSQPTPQL
    61  ENEVSRQHLP ATLPEMVAFY QELHTPTQGQ TMVRQLMHKL LVFSAREVDH RGGCLMLQDT
   121  GISLLIPPGA VAVGRQERVS LILVWDLSDA PSLSQAQGLV SPVVACGPHG ASFLKPCTLT
   181  FKHCAEQPSH ARTYSSNTTL LDAKVWRPLG RPGAHASRDE CRIHLSHFSL YTCVLEAPVG
   241  REARKWLQLA VFCSPLVPGQ SHLQLRIYFL NNTPCALQWA LTNEQPHGGR LRGPCQLFDF
   301  NGARGDQCLK LTYISEGWEN VDDSSCQLVP HLHIWHGKCP FRSFCFRRKA ADENEDCSAL
   361  TNEIIVTMHT FQDGLETKYM EILRFQASEE ESWAAPPPVS QPPPCNRLPP ELFEQLRMLL
   421  EPNSITGNDW RRLASHLGLC GMKIRFLSCQ RSPAAAILEL FEEQNGSLQE LHYLMTVMER
   481  LDCASAIQNY LSGTHGGSPG PERGGARDNQ GLELDEKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNC5CL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 54 nTPM
  • liver: 50 nTPM
  • pancreas: 36 nTPM
  • duodenum: 35 nTPM
  • small intestine: 28 nTPM
  • stomach: 22 nTPM

Single-cell type

  • foveolar cells: 84 nCPM
  • mucous neck cells: 52 nCPM
  • proximal tubule cells: 40 nCPM
  • enterocytes: 36 nCPM
  • hepatocytes: 35 nCPM
  • gastric progenitor cells: 27 nCPM

Immune cell

  • T-reg: 0.4 nTPM
  • gdT-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • white matter: 3.2 nTPM
  • cerebral cortex: 2.2 nTPM
  • medulla oblongata: 2 nTPM
  • basal ganglia: 1.9 nTPM
  • pons: 1.8 nTPM
  • thalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
0.83
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UNC5CL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UNC5CL as an antibody target. Whether an autoantibody or antibody against UNC5CL could matter depends on whether native UNC5CL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UNC5CL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UNC5CL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UNC5CL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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