Netrin receptor UNC5A-D

Definition

This entry represents uncoordinated-5 (UNC-5) family, whose members include Unc5A, B, C and D from vertebrates and Unc5 from invertebrates. UNC-5 proteins are transmembrane netrin receptors that play a crucial role in axon guidance and neuronal development. Upon binding to secreted netrins (netrin-1, -3, and -4), these receptors mediate axonal repulsion of neuronal growth cones, contributing to proper nervous system patterning [[cite:PMID:11454756], [cite:PMID:11387206], [cite:PMID:18266062]]. In addition to axonal guidance, UNC-5 receptors are involved in neuronal migration, blood vessel patterning, cell-cell adhesion, cell migration, and apoptosis [[cite:PMID:24691657], [cite:PMID:28483977]]. Structurally, they possess an extracellular region comprising two immunoglobulin-like repeats and two thrombospondin type-I modules, along with an intracellular region containing ZU-5, UPA, and death domains (DD), which facilitate downstream signalling PMID:17139086.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• UNC5A
• UNC5B
• UNC5C
• UNC5CL
• UNC5D