Seroatlas · Human Serome Atlas

IFT43

Intraflagellar transport protein 43 homolog

Also known as: C14orf179, FLJ32173, IFT43_HUMAN, MGC16028

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96FT9
Gene
IFT43
Ensembl
ENSG00000119650
Chromosome
14
Canonical length
208 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Centriolar satellite,Basal body,Perinuclear theca,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a subunit of the intraflagellar transport complex A (IFT-A). IFT-A is a multiprotein complex that plays an important role in cilia assembly and maintenance by mediating retrograde ciliary transport. Mutations in this gene are a cause of cranioectodermal dysplasia-3 (CED3), also known as Sensenbrenner syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q96FT9|IFT43
     1  MEDLLDLDEE LRYSLATSRA KMGRRAQQES AQAENHLNGK NSSLTLTGET SSAKLPRCRQ
    61  GGWAGDSVKA SKFRRKASEE IEDFRLRPQS LNGSDYGGDI PIIPDLEEVQ EEDFVLQVAA
   121  PPSIQIKRVM TYRDLDNDLM KYSAIQTLDG EIDLKLLTKV LAPEHEVRED DVGWDWDHLF
   181  TEVSSEVLTE WDPLQTEKED PAGQARHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFT43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
84 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 84 nTPM
  • fallopian tube: 61 nTPM
  • epididymis: 47 nTPM
  • heart muscle: 41 nTPM
  • liver: 40 nTPM
  • testis: 40 nTPM

Single-cell type

  • fallopian tube ciliated cells: 383 nCPM
  • respiratory ciliated cells: 366 nCPM
  • choroid plexus epithelial cells: 266 nCPM
  • endometrial ciliated cells: 250 nCPM
  • late primary spermatocytes: 242 nCPM
  • epididymal efferent duct ciliated cells: 229 nCPM

Immune cell

  • basophil: 35 nTPM
  • memory B-cell: 34 nTPM
  • naive CD4 T-cell: 24 nTPM
  • naive CD8 T-cell: 24 nTPM
  • naive B-cell: 23 nTPM
  • plasmacytoid DC: 20 nTPM

Brain region

  • choroid plexus: 34 nTPM
  • midbrain: 18 nTPM
  • medulla oblongata: 18 nTPM
  • spinal cord: 15 nTPM
  • hypothalamus: 15 nTPM
  • white matter: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFT43.

Disease | AllUniProt

Conditions IFT43 is implicated in, by any mechanism.

  • Cranioectodermal dysplasia 3 (CED3) MIM:614099
  • Retinitis pigmentosa 81 (RP81) MIM:617871
  • Short-rib thoracic dysplasia 18 with polydactyly (SRTD18) MIM:617866

Disease | GeneticClinVar

39 pathogenic / likely-pathogenic of 336 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on IFT43 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0
gnomAD missense Z
-0.3
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Intraflagellar transport protein 43
  • Intraflagellar transport protein 43

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFT43 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFT43 as an antibody target. Whether an autoantibody or antibody against IFT43 could matter depends on whether native IFT43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFT43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFT43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFT43. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...