Seroatlas · Human Serome Atlas

UBA2

SUMO-activating enzyme subunit 2

Also known as: FLJ13058, HRIHFB2115, SAE2, SAE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBT2
Gene
UBA2
Ensembl
ENSG00000126261
Chromosome
19
Canonical length
640 aa
Protein class
Disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

Canonical amino-acid sequenceUniProt

640 residues, UniProt reviewed canonical sequence.

>Q9UBT2|UBA2
     1  MALSRGLPRE LAEAVAGGRV LVVGAGGIGC ELLKNLVLTG FSHIDLIDLD TIDVSNLNRQ
    61  FLFQKKHVGR SKAQVAKESV LQFYPKANIV AYHDSIMNPD YNVEFFRQFI LVMNALDNRA
   121  ARNHVNRMCL AADVPLIESG TAGYLGQVTT IKKGVTECYE CHPKPTQRTF PGCTIRNTPS
   181  EPIHCIVWAK YLFNQLFGEE DADQEVSPDR ADPEAAWEPT EAEARARASN EDGDIKRIST
   241  KEWAKSTGYD PVKLFTKLFK DDIRYLLTMD KLWRKRKPPV PLDWAEVQSQ GEETNASDQQ
   301  NEPQLGLKDQ QVLDVKSYAR LFSKSIETLR VHLAEKGDGA ELIWDKDDPS AMDFVTSAAN
   361  LRMHIFSMNM KSRFDIKSMA GNIIPAIATT NAVIAGLIVL EGLKILSGKI DQCRTIFLNK
   421  QPNPRKKLLV PCALDPPNPN CYVCASKPEV TVRLNVHKVT VLTLQDKIVK EKFAMVAPDV
   481  QIEDGKGTIL ISSEEGETEA NNHKKLSEFG IRNGSRLQAD DFLQDYTLLI NILHSEDLGK
   541  DVEFEVVGDA PEKVGPKQAE DAAKSITNGS DDGAQPSTST AQEQDDVLIV DSDEEDSSNN
   601  ADVSEEERSR KRKLDEKENL SAKRSRIEQK EELDDVIALD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
137 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 137 nTPM
  • skeletal muscle: 105 nTPM
  • adipose tissue: 87 nTPM
  • testis: 86 nTPM
  • cerebellum: 67 nTPM
  • breast: 66 nTPM

Single-cell type

  • vascular smooth muscle cells: 388 nCPM
  • pericytes: 320 nCPM
  • myonuclei: 283 nCPM
  • melanocytes: 274 nCPM
  • early primary spermatocytes: 262 nCPM
  • differentiating spermatogonia: 257 nCPM

Immune cell

  • naive CD4 T-cell: 12 nTPM
  • memory CD8 T-cell: 11 nTPM
  • plasmacytoid DC: 10 nTPM
  • MAIT T-cell: 10 nTPM
  • memory CD4 T-cell: 9.5 nTPM
  • naive CD8 T-cell: 9.4 nTPM

Brain region

  • cerebellum: 51 nTPM
  • white matter: 42 nTPM
  • midbrain: 40 nTPM
  • hypothalamus: 40 nTPM
  • thalamus: 38 nTPM
  • cerebral cortex: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBA2.

Disease | AllUniProt

Conditions UBA2 is implicated in, by any mechanism.

Disease | GeneticClinVar

29 pathogenic / likely-pathogenic of 138 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
2.61
DepMap mean gene effect
-1.19
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBA2 as an antibody target. Whether an autoantibody or antibody against UBA2 could matter depends on whether native UBA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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