Seroatlas · Human Serome Atlas

JPT2

Jupiter microtubule associated homolog 2

Also known as: C16orf34, FLJ13092, HN1L, JUPI2_HUMAN, KIAA1426, L11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H910
Gene: JPT2
Ensembl: ENSG00000206053
Chromosome: 16
Canonical length: 190 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Involved in endocytosis involved in viral entry into host cell and regulation of calcium-mediated signaling. Located in cytosol; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>Q9H910|JPT2
     1  MFQVPDSEGG RAGSRAMKPP GGESSNLFGS PEEATPSSRP NRMASNIFGP TEEPQNIPKR
    61  TNPPGGKGSG IFDESTPVQT RQHLNPPGGK TSDIFGSPVT ATSRLAHPNK PKDHVFLCEG
   121  EEPKSDLKAA RSIPAGAEPG EKGSARKAGP AKEQEPMPTV DSHEPRLGPR PRSHNKVLNP
   181  PGGKSSISFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JPT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 117 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 117 nTPM
fallopian tube: 60 nTPM
placenta: 45 nTPM
prostate: 45 nTPM
esophagus: 44 nTPM
liver: 39 nTPM

Single-cell type

extravillous trophoblasts: 283 nCPM
late spermatids: 223 nCPM
syncytiotrophoblasts: 220 nCPM
migrating cytotrophoblasts: 171 nCPM
respiratory ciliated cells: 162 nCPM
fallopian tube ciliated cells: 133 nCPM

Immune cell

naive B-cell: 7.6 nTPM
MAIT T-cell: 7.2 nTPM
NK-cell: 6.8 nTPM
plasmacytoid DC: 6.6 nTPM
naive CD4 T-cell: 6.3 nTPM
T-reg: 5.9 nTPM

Brain region

medulla oblongata: 113 nTPM
white matter: 96 nTPM
pons: 83 nTPM
cerebellum: 60 nTPM
spinal cord: 51 nTPM
midbrain: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.23
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JPT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TPCN1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JPT2 as an antibody target. Whether an autoantibody or antibody against JPT2 could matter depends on whether native JPT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JPT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JPT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...